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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-27
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pubmed:abstractText |
Itch is relieved by scratching, but the neural mechanisms that are responsible for this are unknown. Spinothalamic tract (STT) neurons respond to itch-producing agents and transmit pruritic information to the brain. We observed that scratching the cutaneous receptive field of primate STT neurons produced inhibition during histamine-evoked activity but not during spontaneous activity or activity evoked by a painful stimulus, suggesting that scratching inhibits the transmission of itch in the spinal cord in a state-dependent manner.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1546-1726
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
544-6
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pubmed:dateRevised |
2010-12-28
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pubmed:meshHeading |
pubmed-meshheading:19349977-Action Potentials,
pubmed-meshheading:19349977-Afferent Pathways,
pubmed-meshheading:19349977-Animals,
pubmed-meshheading:19349977-Haplorhini,
pubmed-meshheading:19349977-Histamine,
pubmed-meshheading:19349977-Histamine Agonists,
pubmed-meshheading:19349977-Mechanoreceptors,
pubmed-meshheading:19349977-Neural Inhibition,
pubmed-meshheading:19349977-Neurons,
pubmed-meshheading:19349977-Nociceptors,
pubmed-meshheading:19349977-Physical Stimulation,
pubmed-meshheading:19349977-Pruritus,
pubmed-meshheading:19349977-Sensory Receptor Cells,
pubmed-meshheading:19349977-Skin,
pubmed-meshheading:19349977-Spinothalamic Tracts,
pubmed-meshheading:19349977-Touch
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pubmed:year |
2009
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pubmed:articleTitle |
Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons.
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pubmed:affiliation |
University of Minnesota, Minneapolis, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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