Linked Life Data

19348899

Source:http://linkedlifedata.com/resource/pubmed/id/19348899

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-4-7
pubmed:abstractText
Viral infections frequently alter mitochondrial function with suppression or induction of apoptosis and enhanced generation of reactive oxygen species. The mechanisms of these effects are varied, and mitochondria are affected by both direct interactions with viral proteins and by secondary effects of viral-activated signaling cascades. This chapter describes methods used in our laboratory to assess the effects of the hepatitis C virus core protein on mitochondrial ROS production, electron transport, and Ca(2+) uptake. These include measurements of the effects of in vitro incubation of liver mitochondria with purified core protein and assessment of the function of mitochondria in cells and tissues expressing core and other viral proteins. These methods are generally applicable to the study of viral-mitochondrial interactions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1557-7988
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
456
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-80
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Chapter 20 Effects of hepatitis C core protein on mitochondrial electron transport and production of reactive oxygen species.
pubmed:affiliation
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural