Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2009-5-6
pubmed:abstractText
Gliogenesis in animal development is spatiotemporally regulated so that correct numbers of glia are present to support various neuronal functions. During Drosophila embryonic development, the glial regulatory gene, glial cell missing/glial cell deficient (gcm/glide), promotes glial cell fate and differentiation. Here we describe the ubiquitin-proteasome regulation of the Gcm protein and the consequence in gliogenesis without timely degradation of Gcm. Gcm binds to 2 F-box proteins, Supernumerary limbs (Slimb) and Archipelago (Ago), adaptors of SCF E3 ubiquitin ligases. Ubiquitination and proteasomal degradation of Gcm depend on slimb and ago. In slimb and ago double mutants, Gcm protein levels are enhanced. Concomitantly, glial cell numbers increase owing to proliferation, which can be phenocopied by Gcm overexpression only at the onset of glial differentiation. The glial lineage 5-6A in slimb ago mutants displays excess glial progenies and enhanced Gcm protein levels. We propose that downregulation of Gcm protein levels by Slimb and Ago is required for glial progenitors to exit the cell cycle for differentiation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-10049925, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-11178263, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-11565033, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-12397062, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-12432393, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-12442174, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-12618139, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-12702656, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-14703572, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-15136145, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-15182669, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-15340381, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-15561773, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-15571813, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-15640526, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-15809036, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-16463014, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-16697534, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-17033683, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-17046226, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-17654713, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-18284664, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-18344020, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-7553843, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-7553844, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-7607085, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-8033206, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-8565824, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-8873753, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-9199357, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-9299113, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-9461217, http://linkedlifedata.com/resource/pubmed/commentcorrection/19346490-9671591
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6778-83
pubmed:dateRevised
2010-9-23
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Gcm protein degradation suppresses proliferation of glial progenitors.
pubmed:affiliation
Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't