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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7-8
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pubmed:dateCreated |
2009-6-1
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pubmed:abstractText |
Apigenin, a dietary plant-flavonoid has shown anti-inflammatory and anticancer properties, however the molecular basis of this effect remains to be elucidated. Thus we elucidated to anti-allergic effect of apigenin in ovalbumin (OVA)-induced asthma model mice. The OVA-induced mice showed allergic airway reactions. It included an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid, an increase in inflammatory cell infiltration into the lung around blood vessels and airways, airway luminal narrowing, and the development of airway hyper-responsiveness (AHR). The administration of apigenin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that apigenin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of apigenin in terms of its effects in a murine model of asthma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1878-1705
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pubmed:author |
pubmed-author:ChangJeong HyunJH,
pubmed-author:ChoiIl-WhanIW,
pubmed-author:ChoiJun-RimJR,
pubmed-author:JeongYoung-IlYI,
pubmed-author:JungIn DukID,
pubmed-author:KimJong-SukJS,
pubmed-author:LeeChang-MinCM,
pubmed-author:LeeJun SikJS,
pubmed-author:ParkHee-JuHJ,
pubmed-author:ParkSung NamSN,
pubmed-author:ParkYeong-MinYM,
pubmed-author:ShinYong KyooYK
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
918-24
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pubmed:meshHeading |
pubmed-meshheading:19345747-Airway Obstruction,
pubmed-meshheading:19345747-Animals,
pubmed-meshheading:19345747-Apigenin,
pubmed-meshheading:19345747-Asthma,
pubmed-meshheading:19345747-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:19345747-Cell Movement,
pubmed-meshheading:19345747-Cytokines,
pubmed-meshheading:19345747-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19345747-Eosinophil Peroxidase,
pubmed-meshheading:19345747-Eosinophilia,
pubmed-meshheading:19345747-Eosinophils,
pubmed-meshheading:19345747-Female,
pubmed-meshheading:19345747-GATA3 Transcription Factor,
pubmed-meshheading:19345747-Immunization,
pubmed-meshheading:19345747-Immunoglobulin E,
pubmed-meshheading:19345747-Lung,
pubmed-meshheading:19345747-Matrix Metalloproteinase 9,
pubmed-meshheading:19345747-Mice,
pubmed-meshheading:19345747-Mice, Inbred BALB C,
pubmed-meshheading:19345747-Ovalbumin
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pubmed:year |
2009
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pubmed:articleTitle |
Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene.
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pubmed:affiliation |
Department of Microbiology and Immunology, Pusan National University School of Medicine, Busan 602-739, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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