rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-8-31
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pubmed:abstractText |
Cholesteryl ester transfer protein (CETP) adversely affects the plasma lipoprotein profile by increasing VLDL-cholesterol and decreasing HDL-cholesterol. The relative contribution of either of these changes to atherosclerosis development is not known. We investigated to what extent the increase in VLDL-cholesterol can explain the atherogenic action of human CETP expression in APOE*3-Leiden (E3L) mice, a model for human-like lipoprotein metabolism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/CETP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Ester Transfer Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Amyloid A Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1879-1484
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
206
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-8
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pubmed:meshHeading |
pubmed-meshheading:19345354-Animals,
pubmed-meshheading:19345354-Apolipoproteins E,
pubmed-meshheading:19345354-Atherosclerosis,
pubmed-meshheading:19345354-Cholesterol, HDL,
pubmed-meshheading:19345354-Cholesterol, VLDL,
pubmed-meshheading:19345354-Cholesterol Ester Transfer Proteins,
pubmed-meshheading:19345354-E-Selectin,
pubmed-meshheading:19345354-Female,
pubmed-meshheading:19345354-Fibrinogen,
pubmed-meshheading:19345354-Humans,
pubmed-meshheading:19345354-Inflammation,
pubmed-meshheading:19345354-Mice,
pubmed-meshheading:19345354-Serum Amyloid A Protein
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pubmed:year |
2009
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pubmed:articleTitle |
Human CETP aggravates atherosclerosis by increasing VLDL-cholesterol rather than by decreasing HDL-cholesterol in APOE*3-Leiden mice.
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pubmed:affiliation |
The Netherlands Organization for Applied Scientific Research-BioSciences, Gaubius Laboratory, Leiden, The Netherlands. a.j.de vries@lumc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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