Source:http://linkedlifedata.com/resource/pubmed/id/19344432
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2009-5-8
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| pubmed:abstractText |
No treatment has consistently induced long-term remission of proteinuria in adult patients with focal segmental glomerulosclerosis (FSGS) recurrence after kidney transplantation. We undertook an open-label, nonrandomized pilot trial of intensive and prolonged treatment of FSGS recurrence. Over an 18-month period, 10 adult kidney transplant recipients with FSGS recurrence received concomitantly high-dose steroids, intravenous cyclosporine for 14 days followed by oral cyclosporine therapy, and an intensive and prolonged course of plasma exchanges (PE). We compared this treatment with those of a control group of 19 patients with a FSGS recurrence transplanted between 1997 and 2005. Complete, rapid (mean 23 +/- 7 days) and sustained remission was obtained in 9/10 patients (90%) as opposed to 27% in the control group. At month 3 and month 12, proteinuria was 0.16 g/day (range 0.05-0.3 g/day) and 0.19 g/day (range 0.05-1 g/day) respectively. Only one patient remained in partial remission at month 12 but he had already lost two previous grafts due to FSGS recurrence. PEs were stopped at month 9 in all patients except for the patient with a partial remission who remains PE-dependent. This small pilot study provides very encouraging results demonstrating that this treatment rapidly achieves complete and sustained remission in a high proportion of patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1600-6143
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| pubmed:author |
pubmed-author:AnglicheauDD,
pubmed-author:CanauxSS,
pubmed-author:Cavazzana-CalvoMM,
pubmed-author:GahlFF,
pubmed-author:LefrèreFF,
pubmed-author:LegendreChCh,
pubmed-author:MéjeanAA,
pubmed-author:MartinezFF,
pubmed-author:NairC VCV,
pubmed-author:RoyaleVV,
pubmed-author:SberroRR,
pubmed-author:SnanoudjRR,
pubmed-author:ThervetEE,
pubmed-author:ZuberJJ
|
| pubmed:issnType |
Electronic
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| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1081-6
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| pubmed:meshHeading |
pubmed-meshheading:19344432-Adolescent,
pubmed-meshheading:19344432-Adult,
pubmed-meshheading:19344432-Age of Onset,
pubmed-meshheading:19344432-Child,
pubmed-meshheading:19344432-Child, Preschool,
pubmed-meshheading:19344432-Continental Population Groups,
pubmed-meshheading:19344432-Disease Progression,
pubmed-meshheading:19344432-Drug Therapy, Combination,
pubmed-meshheading:19344432-Female,
pubmed-meshheading:19344432-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:19344432-Humans,
pubmed-meshheading:19344432-Immunosuppressive Agents,
pubmed-meshheading:19344432-Kidney Failure, Chronic,
pubmed-meshheading:19344432-Kidney Transplantation,
pubmed-meshheading:19344432-Male,
pubmed-meshheading:19344432-Pilot Projects,
pubmed-meshheading:19344432-Proteinuria,
pubmed-meshheading:19344432-Recurrence,
pubmed-meshheading:19344432-Remission Induction,
pubmed-meshheading:19344432-Retrospective Studies,
pubmed-meshheading:19344432-Tissue Donors,
pubmed-meshheading:19344432-Young Adult
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Intensive and prolonged treatment of focal and segmental glomerulosclerosis recurrence in adult kidney transplant recipients: a pilot study.
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| pubmed:affiliation |
Université Paris Descartes, 7 Rue de l'Ecole de Médecine, Paris 75007, France. guillaume.canaud@nck.aphp.fr
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| pubmed:publicationType |
Journal Article
|