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pubmed-article:19344190pubmed:abstractTextHuman follicle-stimulating hormone (hFSH; follitropin alfa) can be employed therapeutically to induce ovarian follicular development in assisted reproduction treatments. Current recombinant hFSH (r-hFSH) preparations available for clinical use are labeled either in terms of the bioactivity expressed in international units (IU) or in mass (microg). Several clinical trials have tried to assess the clinical implications of the physicochemical improvements in the dosing of follitropin alfa filled by mass (FbM). The aim of this study was to perform a meta-analysis of previous studies in order to assess the efficacy and safety of ovarian stimulation using follitropin alfa FbM compared with follitropin alfa filled by international units (FbIU).lld:pubmed
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pubmed-article:19344190pubmed:articleTitleOutcomes of new quality standards of follitropin alfa on ovarian stimulation: meta-analysis of previous studies.lld:pubmed
pubmed-article:19344190pubmed:affiliationAgencia de Evaluación de Tecnologías Sanitarias, Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Madrid, Spain. zuleika@isciii.eslld:pubmed
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