pubmed-article:19343259 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:19343259 | lifeskim:mentions | umls-concept:C0043227 | lld:lifeskim |
pubmed-article:19343259 | lifeskim:mentions | umls-concept:C0018873 | lld:lifeskim |
pubmed-article:19343259 | lifeskim:mentions | umls-concept:C0010798 | lld:lifeskim |
pubmed-article:19343259 | lifeskim:mentions | umls-concept:C1332320 | lld:lifeskim |
pubmed-article:19343259 | lifeskim:mentions | umls-concept:C1554124 | lld:lifeskim |
pubmed-article:19343259 | lifeskim:mentions | umls-concept:C1563350 | lld:lifeskim |
pubmed-article:19343259 | lifeskim:mentions | umls-concept:C1563351 | lld:lifeskim |
pubmed-article:19343259 | pubmed:issue | 8 | lld:pubmed |
pubmed-article:19343259 | pubmed:dateCreated | 2009-4-3 | lld:pubmed |
pubmed-article:19343259 | pubmed:abstractText | The suppressive effects of synthetic dendrimers on mitochondrial apoptosis were first demonstrated in human epithelial carcinoma HeLa cells. The employed proteo-dendrimers included polyanionic hepta(glutamic acids), a fluorescent zinc porphyrinate core, hydrophilic polyether surface and nonpeptide hydrophobic dendrons, and electrostatically interacted with cytochrome c in aqueous solutions. The ceramide analogue, (2S,4E)-2-acetylamino-3-oxo-4-octadecen-1-ol (C2-ketoCer) induced mitochondrial apoptosis into HeLa cells and the cell viability was significantly recovered by pretreatment with some dendrimers. Among a series of proteo-dendrimers, the second-generation dendrimer 2a had the lowest cytotoxicity and the highest solubility. When the cells were treated with this dendrimer, a decrease in the protein levels of active caspase-3 and proteolytically cleaved PARP was remarkably observed. Since cytochrome c release from the mitochondria to the cytoplasm was unaffected in the presence of dendrimer 2a, the observed suppressive effects probably indicate that the proteo-dendrimer trapped cytochrome c, not only in the aqueous solutions but also in the living cells.. | lld:pubmed |
pubmed-article:19343259 | pubmed:language | eng | lld:pubmed |
pubmed-article:19343259 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19343259 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:19343259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19343259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19343259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19343259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19343259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19343259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19343259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19343259 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:19343259 | pubmed:month | Apr | lld:pubmed |
pubmed-article:19343259 | pubmed:issn | 1477-0539 | lld:pubmed |
pubmed-article:19343259 | pubmed:author | pubmed-author:NagasakiTakes... | lld:pubmed |
pubmed-article:19343259 | pubmed:author | pubmed-author:ShinodaSatosh... | lld:pubmed |
pubmed-article:19343259 | pubmed:author | pubmed-author:AzumaHidekiH | lld:pubmed |
pubmed-article:19343259 | pubmed:author | pubmed-author:TsukubeHirosh... | lld:pubmed |
pubmed-article:19343259 | pubmed:author | pubmed-author:PaulDharamD | lld:pubmed |
pubmed-article:19343259 | pubmed:author | pubmed-author:YoshidaYuukaY | lld:pubmed |
pubmed-article:19343259 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:19343259 | pubmed:day | 21 | lld:pubmed |
pubmed-article:19343259 | pubmed:volume | 7 | lld:pubmed |
pubmed-article:19343259 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:19343259 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:19343259 | pubmed:pagination | 1700-4 | lld:pubmed |
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pubmed-article:19343259 | pubmed:year | 2009 | lld:pubmed |
pubmed-article:19343259 | pubmed:articleTitle | Cytochrome c-binding "proteo-dendrimers" as new types of apoptosis inhibitors working in HeLa cell systems. | lld:pubmed |
pubmed-article:19343259 | pubmed:affiliation | Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University, Sugimoto 3-3-138, Sumiyoshi-ku, Osaka, 558-8585, Japan. azumah@bioa.eng.osaka-cu.ac.jp | lld:pubmed |
pubmed-article:19343259 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:19343259 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |