|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
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|
pubmed:dateCreated |
1991-12-12
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|
pubmed:abstractText |
Novel 36 derivatives (6), bonding the phenolic hydroxyl group of 7-ethyl-10-hydroxycamptothecin (4) with diamines through a monocarbamate linkage, were synthesized and their antitumor activity was evaluated in vivo. The derivatives were soluble in water as their HCl salts with the E lactone ring intact and exhibited significant antitumor activity. One of the derivatives, 6-27 showed excellent activity against L1210 leukemia and other murine tumors. The structure of its hydrochloride trihydrate (CPT-11) was determined by spectroscopic and crystallographic methods.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jun
|
|
pubmed:issn |
0009-2363
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
39
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1446-50
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|
pubmed:dateRevised |
2007-9-25
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|
pubmed:meshHeading |
pubmed-meshheading:1934165-Animals,
pubmed-meshheading:1934165-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:1934165-Camptothecin,
pubmed-meshheading:1934165-Carbamates,
pubmed-meshheading:1934165-Female,
pubmed-meshheading:1934165-Leukemia L1210,
pubmed-meshheading:1934165-Mice,
pubmed-meshheading:1934165-Mice, Inbred BALB C,
pubmed-meshheading:1934165-Mice, Inbred ICR,
pubmed-meshheading:1934165-Solubility,
pubmed-meshheading:1934165-Water
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|
pubmed:year |
1991
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|
pubmed:articleTitle |
Synthesis and antitumor activity of 20(S)-camptothecin derivatives: carbamate-linked, water-soluble derivatives of 7-ethyl-10-hydroxycamptothecin.
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|
pubmed:affiliation |
Yakult Institute for Microbiological Research, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
|
