Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-12-13
pubmed:abstractText
LAP, a transcriptional activator, and LIP, a transcriptional repressor, are translated from a single mRNA species by using two AUGs within the same reading frame. These two proteins share the 145 C-terminal amino acids that contain the basic DNA-binding domain and the leucine zipper dimerization helix. Probably owing to its higher affinity for its DNA cognate sequences, LIP can attenuate the transcriptional stimulation by LAP in substoichiometric amounts. As revealed by transient transfection experiments, a moderate increase in the LAP/LIP ratio results in a significantly higher transcriptional activation of an appropriate target gene. The LAP/LIP ratio increases about 5-fold during terminal rat liver differentiation and is thus likely to modulate the activity of LAP in the intact animal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
569-79
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1934061-Animals, pubmed-meshheading:1934061-Base Sequence, pubmed-meshheading:1934061-CCAAT-Enhancer-Binding Proteins, pubmed-meshheading:1934061-Cell Differentiation, pubmed-meshheading:1934061-DNA Mutational Analysis, pubmed-meshheading:1934061-DNA-Binding Proteins, pubmed-meshheading:1934061-Gene Expression Regulation, pubmed-meshheading:1934061-Genes, pubmed-meshheading:1934061-Leucine Zippers, pubmed-meshheading:1934061-Liver, pubmed-meshheading:1934061-Molecular Sequence Data, pubmed-meshheading:1934061-Protein Biosynthesis, pubmed-meshheading:1934061-RNA, Messenger, pubmed-meshheading:1934061-Rats, pubmed-meshheading:1934061-Repressor Proteins, pubmed-meshheading:1934061-Ribosomes, pubmed-meshheading:1934061-Transcription, Genetic, pubmed-meshheading:1934061-Transcription Factors
pubmed:year
1991
pubmed:articleTitle
A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA.
pubmed:affiliation
Département de Biologie Moléculaire Sciences II, Geneve, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't