| pubmed-article:1934059 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1934059 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:1934059 | lifeskim:mentions | umls-concept:C0035736 | lld:lifeskim |
| pubmed-article:1934059 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:1934059 | lifeskim:mentions | umls-concept:C0600436 | lld:lifeskim |
| pubmed-article:1934059 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1934059 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:1934059 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1934059 | pubmed:dateCreated | 1991-12-13 | lld:pubmed |
| pubmed-article:1934059 | pubmed:abstractText | We have used an iterative in vitro genetic selection to identify the important structural features of the viral RNA element bound by the Rev protein of human immunodeficiency virus type 1 (HIV-1). Functional Rev-binding RNAs were selected from a pool of 10(13) variants of the wild-type Rev-binding domain. Bases conserved among the binding species define a 20 nucleotide core binding element. Covariation of some of these conserved bases indicates that the Rev-binding element is a stem-bulge-stem with a G:G base pair in the bulge. Mutational studies show that this non-Watson-Crick base pair is required for Rev binding in vitro and Rev responsiveness in vivo. We propose that the G:G base pair distorts the sugar-phosphate backbone of viral RNA and that this distortion is a critical determinant of recognition by Rev. | lld:pubmed |
| pubmed-article:1934059 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1934059 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1934059 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1934059 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1934059 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1934059 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:1934059 | pubmed:author | pubmed-author:GreenM RMR | lld:pubmed |
| pubmed-article:1934059 | pubmed:author | pubmed-author:SzostakJ WJW | lld:pubmed |
| pubmed-article:1934059 | pubmed:author | pubmed-author:ZappM LML | lld:pubmed |
| pubmed-article:1934059 | pubmed:author | pubmed-author:BartelD PDP | lld:pubmed |
| pubmed-article:1934059 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1934059 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1934059 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:1934059 | pubmed:geneSymbol | rev | lld:pubmed |
| pubmed-article:1934059 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1934059 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1934059 | pubmed:pagination | 529-36 | lld:pubmed |
| pubmed-article:1934059 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1934059 | pubmed:meshHeading | pubmed-meshheading:1934059-... | lld:pubmed |
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| pubmed-article:1934059 | pubmed:meshHeading | pubmed-meshheading:1934059-... | lld:pubmed |
| pubmed-article:1934059 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1934059 | pubmed:articleTitle | HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. | lld:pubmed |
| pubmed-article:1934059 | pubmed:affiliation | Department of Molecular Biology, Massachusetts General Hospital, Boston 02114. | lld:pubmed |
| pubmed-article:1934059 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1934059 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1934059 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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