| pubmed-article:19339598 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19339598 | lifeskim:mentions | umls-concept:C0018496 | lld:lifeskim |
| pubmed-article:19339598 | lifeskim:mentions | umls-concept:C0205101 | lld:lifeskim |
| pubmed-article:19339598 | lifeskim:mentions | umls-concept:C0205102 | lld:lifeskim |
| pubmed-article:19339598 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:19339598 | lifeskim:mentions | umls-concept:C0392673 | lld:lifeskim |
| pubmed-article:19339598 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:19339598 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:19339598 | lifeskim:mentions | umls-concept:C0456962 | lld:lifeskim |
| pubmed-article:19339598 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:19339598 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:19339598 | pubmed:dateCreated | 2009-4-2 | lld:pubmed |
| pubmed-article:19339598 | pubmed:abstractText | In inner ear hair cells, activation of mechanotransduction channels is followed by extremely rapid deactivation that depends on the influx of Ca(2+) through these channels. Although the molecular mechanisms of this "fast" adaptation are largely unknown, the predominant models assume Ca(2+) sensitivity as an intrinsic property of yet unidentified mechanotransduction channels. Here, we examined mechanotransduction in the hair cells of young postnatal shaker 2 mice (Myo15(sh2/sh2)). These mice have no functional myosin-XVa, which is critical for normal growth of mechanosensory stereocilia of hair cells. Although stereocilia of both inner and outer hair cells of Myo15(sh2/sh2) mice lack myosin-XVa and are abnormally short, these cells have dramatically different hair bundle morphology. Myo15(sh2/sh2) outer hair cells retain a staircase arrangement of the abnormally short stereocilia and prominent tip links. Myo15(sh2/sh2) inner hair cells do not have obliquely oriented tip links, and their mechanosensitivity is mediated exclusively by "top-to-top" links between equally short stereocilia. In both inner and outer hair cells of Myo15(sh2/sh2) mice, we found mechanotransduction responses with a normal "wild-type" amplitude and speed of activation. Surprisingly, only outer hair cells exhibit fast adaptation and sensitivity to extracellular Ca(2+). In Myo15(sh2/sh2) inner hair cells, fast adaptation is disrupted and the transduction current is insensitive to extracellular Ca(2+). We conclude that the Ca(2+) sensitivity of the mechanotransduction channels and the fast adaptation require a structural environment that is dependent on myosin-XVa and is disrupted in Myo15(sh2/sh2) inner hair cells, but not in Myo15(sh2/sh2) outer hair cells. | lld:pubmed |
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| pubmed-article:19339598 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19339598 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19339598 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19339598 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19339598 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19339598 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:19339598 | pubmed:author | pubmed-author:FrolenkovGreg... | lld:pubmed |
| pubmed-article:19339598 | pubmed:author | pubmed-author:StepanyanRube... | lld:pubmed |
| pubmed-article:19339598 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19339598 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19339598 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:19339598 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19339598 | pubmed:authorsComplete | Y | lld:pubmed |
