Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2009-4-2
pubmed:abstractText
In inner ear hair cells, activation of mechanotransduction channels is followed by extremely rapid deactivation that depends on the influx of Ca(2+) through these channels. Although the molecular mechanisms of this "fast" adaptation are largely unknown, the predominant models assume Ca(2+) sensitivity as an intrinsic property of yet unidentified mechanotransduction channels. Here, we examined mechanotransduction in the hair cells of young postnatal shaker 2 mice (Myo15(sh2/sh2)). These mice have no functional myosin-XVa, which is critical for normal growth of mechanosensory stereocilia of hair cells. Although stereocilia of both inner and outer hair cells of Myo15(sh2/sh2) mice lack myosin-XVa and are abnormally short, these cells have dramatically different hair bundle morphology. Myo15(sh2/sh2) outer hair cells retain a staircase arrangement of the abnormally short stereocilia and prominent tip links. Myo15(sh2/sh2) inner hair cells do not have obliquely oriented tip links, and their mechanosensitivity is mediated exclusively by "top-to-top" links between equally short stereocilia. In both inner and outer hair cells of Myo15(sh2/sh2) mice, we found mechanotransduction responses with a normal "wild-type" amplitude and speed of activation. Surprisingly, only outer hair cells exhibit fast adaptation and sensitivity to extracellular Ca(2+). In Myo15(sh2/sh2) inner hair cells, fast adaptation is disrupted and the transduction current is insensitive to extracellular Ca(2+). We conclude that the Ca(2+) sensitivity of the mechanotransduction channels and the fast adaptation require a structural environment that is dependent on myosin-XVa and is disrupted in Myo15(sh2/sh2) inner hair cells, but not in Myo15(sh2/sh2) outer hair cells.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-10234008, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-10561397, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-10588701, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-11007868, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-11050202, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-11050203, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-11495929, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-11549711, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-11753415, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-11853671, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-12124769, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-12239568, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-12486594, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-12538849, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-12764092, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-12805294, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-12872124, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-14552426, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-14610277, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-14659096, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-14977412, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-15024034, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-1527581, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-15654330, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-15696193, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-15776440, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-15994187, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-16102537, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-16120785, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-16206170, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-16214875, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-16371947, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-16775142, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-16807332, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-16973713, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-17021180, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-17065441, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-1708822, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-17173047, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-17546645, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-1764247, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-17704173, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-17891720, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-17942617, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-18077701, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-18391215, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-18466744, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-18760690, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-18801844, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-2468161, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-2483095, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-2555460, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-2621635, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-3429352, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-3495007, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-3713830, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-45121, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-6436216, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-7568224, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-7884037, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-8407602, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-8458761, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-8845155, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-8986835, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-9284333, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-9481679, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-9529344, http://linkedlifedata.com/resource/pubmed/commentcorrection/19339598-9603735
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
More...