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rdf:type |
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lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0030705,
umls-concept:C0070166,
umls-concept:C0205341,
umls-concept:C0205419,
umls-concept:C0376249,
umls-concept:C0596545,
umls-concept:C0948089,
umls-concept:C1176140,
umls-concept:C1332828,
umls-concept:C1332829,
umls-concept:C1413882
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pubmed:issue |
2
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pubmed:dateCreated |
2009-4-1
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pubmed:abstractText |
The presence of cytochrome P450 (CYP) variant alleles may reduce the activation of the prodrug clopidogrel to its active state. This research evaluated the frequency of variant alleles in the genes coding for CYP3A4, CYP3A5, CYP2C9, and CYP2C19 enzymes in patients on clopidogrel therapy and experiencing repeat acute coronary syndrome (ACS) compared to a control group with a matching ethnic composition. Real-time polymerase chain reaction was used for allelic discrimination. Complete data were obtained for 92 patients enrolled over a 3-month period. There were no significant differences in the presence of the examined CYP3A4, CYP3A5, CYP2C9, or CYP2C19 variant alleles between the two groups. The present data indicate that patients currently receiving clopidogrel therapy who present with repeat ACS do not have higher frequency of the examined variant alleles compared to a control group.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/CYP2C19 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CYP2C9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Ticlopidine,
http://linkedlifedata.com/resource/pubmed/chemical/clopidogrel
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1615-2573
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
73-8
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pubmed:meshHeading |
pubmed-meshheading:19337788-Acute Coronary Syndrome,
pubmed-meshheading:19337788-Aged,
pubmed-meshheading:19337788-Aged, 80 and over,
pubmed-meshheading:19337788-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:19337788-Cytochrome P-450 CYP3A,
pubmed-meshheading:19337788-Drug Resistance,
pubmed-meshheading:19337788-Female,
pubmed-meshheading:19337788-Gene Frequency,
pubmed-meshheading:19337788-Genetic Variation,
pubmed-meshheading:19337788-Genotype,
pubmed-meshheading:19337788-Humans,
pubmed-meshheading:19337788-Male,
pubmed-meshheading:19337788-Middle Aged,
pubmed-meshheading:19337788-Phenotype,
pubmed-meshheading:19337788-Platelet Aggregation Inhibitors,
pubmed-meshheading:19337788-Prospective Studies,
pubmed-meshheading:19337788-Recurrence,
pubmed-meshheading:19337788-Ticlopidine,
pubmed-meshheading:19337788-Treatment Failure
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pubmed:year |
2009
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pubmed:articleTitle |
Frequency of CYP3A4, CYP3A5, CYP2C9, and CYP2C19 variant alleles in patients receiving clopidogrel that experience repeat acute coronary syndrome.
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pubmed:affiliation |
Department of Pharmacy Practice, Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA 22601-9975, USA. mbrackbi@su.edu
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pubmed:publicationType |
Journal Article,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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