Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-4-1
pubmed:abstractText
Sitagliptin and vildagliptin represent a new class of anti-diabetic agents that enhance the action of incretin hormones through inhibition of dipeptidyl peptidase-4 (DPP-4), the enzyme that normally inactivates incretin hormones. Because of their distinct mechanism of action, DPP-4 inhibitors can be used as add-on therapy to other classes of drugs for treatment of type 2 diabetes. The objective of this review is to critically evaluate clinical trials of sitagliptin and vildagliptin in combination with pioglitazone. The addition of either sitagliptin or vildagliptin to ongoing pioglitazone therapy is associated with reduction in average hemoglobin A1c (HbA1c) levels of approximately 0.7% compared with placebo and 1% compared with baseline after 24 weeks. When started concomitantly in drug-naïve patients, the combination of pioglitazone 30 mg and vildagliptin 100 mg qd reduces HbA1c by 1.9% after 24 weeks, compared with 1.1% with pioglitazone monotherapy. In general, the addition of DPP-4 inhibitors to pioglitazone was well tolerated, did not increase the incidence of hypoglycemia, and did not substantially worsen the weight-gain induced by pioglitazone. The combination of sitagliptpin or vildagliptin with pioglitazone can be a useful therapeutic approach in patients with type 2 diabetes who cannot tolerate metformin or a sulfonylurea.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-12519856, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-12680885, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-12962163, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-15356308, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-15562200, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-16214598, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-16823726, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-16873813, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17001471, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17098089, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17130196, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17157112, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17195423, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17223217, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17300592, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17300593, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17300595, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17303799, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17485570, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17559733, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17638715, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-17909087, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-18042650, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337535-18518892
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adamantane, http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose, http://linkedlifedata.com/resource/pubmed/chemical/DPP4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Dipeptidyl Peptidase 4, http://linkedlifedata.com/resource/pubmed/chemical/Dipeptidyl-Peptidase IV Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated, http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Insulin, http://linkedlifedata.com/resource/pubmed/chemical/Lipids, http://linkedlifedata.com/resource/pubmed/chemical/Nitriles, http://linkedlifedata.com/resource/pubmed/chemical/Pyrazines, http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines, http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones, http://linkedlifedata.com/resource/pubmed/chemical/Triazoles, http://linkedlifedata.com/resource/pubmed/chemical/hemoglobin A1c protein, human, http://linkedlifedata.com/resource/pubmed/chemical/pioglitazone, http://linkedlifedata.com/resource/pubmed/chemical/sitagliptin, http://linkedlifedata.com/resource/pubmed/chemical/vildagliptin
pubmed:status
MEDLINE
pubmed:issn
1178-2048
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1221-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:19337535-Adamantane, pubmed-meshheading:19337535-Blood Glucose, pubmed-meshheading:19337535-Body Weight, pubmed-meshheading:19337535-Clinical Trials as Topic, pubmed-meshheading:19337535-Diabetes Mellitus, Type 2, pubmed-meshheading:19337535-Dipeptidyl Peptidase 4, pubmed-meshheading:19337535-Dipeptidyl-Peptidase IV Inhibitors, pubmed-meshheading:19337535-Drug Therapy, Combination, pubmed-meshheading:19337535-Edema, pubmed-meshheading:19337535-Hemoglobin A, Glycosylated, pubmed-meshheading:19337535-Humans, pubmed-meshheading:19337535-Hypoglycemic Agents, pubmed-meshheading:19337535-Insulin, pubmed-meshheading:19337535-Lipids, pubmed-meshheading:19337535-Nitriles, pubmed-meshheading:19337535-Pyrazines, pubmed-meshheading:19337535-Pyrrolidines, pubmed-meshheading:19337535-Thiazolidinediones, pubmed-meshheading:19337535-Treatment Outcome, pubmed-meshheading:19337535-Triazoles
pubmed:year
2008
pubmed:articleTitle
Combination therapy with DPP-4 inhibitors and pioglitazone in type 2 diabetes: theoretical consideration and therapeutic potential.
pubmed:affiliation
Endocrinology Division, Olive View-UCLA Medical Center, David Geffen School of Medicine, 14445 Olive View Drive, Sylmar, CA 91342, USA. nmikhail@ladhs.org
pubmed:publicationType
Journal Article, Review