Linked Life Data

19337415

Source:http://linkedlifedata.com/resource/pubmed/id/19337415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-4-1
pubmed:abstractText
The overproduction of hydrogen peroxide is implicated in the progress of numerous life-threatening diseases and there is a great need for the development of contrast agents that can detect hydrogen peroxide in vivo. In this communication, we present a new contrast agent for hydrogen peroxide, termed peroxalate micelles, which detect hydrogen peroxide through chemiluminescence, and have the physical/chemical properties needed for in vivo imaging applications. The peroxalate micelles are composed of amphiphilic peroxalate based copolymers and the fluorescent dye rubrene, they have a 'stealth' polyethylene glycol (PEG) corona to evade macrophage phagocytosis, and a diameter of 33 nm to enhance extravasation into permeable tissues. The peroxalate micelles can detect nanomolar concentrations of hydrogen peroxide (>50 nM) and thus have the sensitivity needed to detect physiological concentrations of hydrogen peroxide. We anticipate numerous applications of the peroxalate micelles for in vivo imaging of hydrogen peroxide, given their high sensitivity, small size, and biocompatible PEG corona.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-11897148, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-12375960, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-14759598, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-14986866, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-15031496, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-15563161, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-16305254, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-16502395, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-17090068, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-17704780, http://linkedlifedata.com/resource/pubmed/commentcorrection/19337415-18654426
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1178-2013
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
471-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Detection of hydrogen peroxide with chemiluminescent micelles.
pubmed:affiliation
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural