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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3 Suppl
|
| pubmed:dateCreated |
1991-12-19
|
| pubmed:abstractText |
Altered chromatin conformation and increased amounts of aluminum have been observed in the brains of patients with Alzheimer disease. These factors have been shown to affect gene regulation. In this report, we describe how these changes may selectively alter the pool size of the human light chain neurofilament gene and play a fundamental role in the expression of this disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0317-1671
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:geneSymbol |
HNF-L
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
414-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1933691-Alzheimer Disease,
pubmed-meshheading:1933691-Analysis of Variance,
pubmed-meshheading:1933691-Cerebral Cortex,
pubmed-meshheading:1933691-Chromatin,
pubmed-meshheading:1933691-Down-Regulation,
pubmed-meshheading:1933691-Gene Expression,
pubmed-meshheading:1933691-Histones,
pubmed-meshheading:1933691-Humans,
pubmed-meshheading:1933691-RNA, Messenger
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Anomalous gene expression in Alzheimer disease: cause or effect.
|
| pubmed:affiliation |
Centre for Research in Neurodegenerative Disease, University of Toronto, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|