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rdf:type |
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lifeskim:mentions |
umls-concept:C0002708,
umls-concept:C0011570,
umls-concept:C0086418,
umls-concept:C0107103,
umls-concept:C0183683,
umls-concept:C0344211,
umls-concept:C0449468,
umls-concept:C0814299,
umls-concept:C1171411,
umls-concept:C1317973,
umls-concept:C1521721,
umls-concept:C1705117,
umls-concept:C1882417
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pubmed:issue |
11
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pubmed:dateCreated |
2009-10-5
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pubmed:abstractText |
The role of the brain-derived neurotrophic factor (BDNF) in the pathogenesis of affective disorders such as depression has been controversial. Mounting evidence comes from structural imaging, that the functional BDNF Val66Met polymorphism influences the hippocampal volume with carriers of the 66Met allele (Val/Met and Met/Met group) having smaller hippocampi. Given that stress-induced atrophy of the hippocampus is associated with the pathogenesis of affective disorders, the functional BDNF Val66Met polymorphism could be an incremental risk factor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1469-8978
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1831-9
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pubmed:meshHeading |
pubmed-meshheading:19335934-Adult,
pubmed-meshheading:19335934-Alleles,
pubmed-meshheading:19335934-Amygdala,
pubmed-meshheading:19335934-Atrophy,
pubmed-meshheading:19335934-Brain,
pubmed-meshheading:19335934-Brain Mapping,
pubmed-meshheading:19335934-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:19335934-Depressive Disorder,
pubmed-meshheading:19335934-Dominance, Cerebral,
pubmed-meshheading:19335934-Female,
pubmed-meshheading:19335934-Frontal Lobe,
pubmed-meshheading:19335934-Genetic Predisposition to Disease,
pubmed-meshheading:19335934-Genotype,
pubmed-meshheading:19335934-Heterozygote Detection,
pubmed-meshheading:19335934-Hippocampus,
pubmed-meshheading:19335934-Humans,
pubmed-meshheading:19335934-Image Processing, Computer-Assisted,
pubmed-meshheading:19335934-Magnetic Resonance Imaging,
pubmed-meshheading:19335934-Male,
pubmed-meshheading:19335934-Parahippocampal Gyrus,
pubmed-meshheading:19335934-Polymorphism, Genetic,
pubmed-meshheading:19335934-Reference Values,
pubmed-meshheading:19335934-Risk Factors,
pubmed-meshheading:19335934-Thalamus,
pubmed-meshheading:19335934-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression.
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pubmed:affiliation |
Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Germany. christian.montag@uni-bonn-diff.de
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pubmed:publicationType |
Journal Article
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