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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
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pubmed:dateCreated |
2009-4-1
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|
pubmed:abstractText |
B cell-activating factor of the TNF family (BAFF) is critical for B cell maturation and survival. Here, we constructed a stable CHO cell line, in which the expression level of soluble form of BAFF (sBAFF) was raised from 0.13 microg/ml to 0.55 microg/ml. Purified recombinant sBAFF from these CHO cells not only bound to its receptors but also co-stimulated the proliferation of human peripheral blood B lymphocyte in vitro. These results provided us with a useful basis for further studies about sBAFF-related research.
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pubmed:language |
rus
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
0026-8984
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
43
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
85-90
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pubmed:meshHeading |
pubmed-meshheading:19334529-Animals,
pubmed-meshheading:19334529-B-Cell Activating Factor,
pubmed-meshheading:19334529-B-Cell Activation Factor Receptor,
pubmed-meshheading:19334529-B-Lymphocytes,
pubmed-meshheading:19334529-CHO Cells,
pubmed-meshheading:19334529-Cell Proliferation,
pubmed-meshheading:19334529-Cricetinae,
pubmed-meshheading:19334529-Cricetulus,
pubmed-meshheading:19334529-Gene Expression,
pubmed-meshheading:19334529-Humans,
pubmed-meshheading:19334529-Recombinant Proteins
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|
pubmed:articleTitle |
[Expression, characterization of recombinant human soluble BAFF secreted from CHO cell].
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|
pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
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