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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-4-7
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pubmed:abstractText |
The co-occurrence of different autoimmune diseases in patients and their families suggests the presence of shared genetic risk factors. Two compelling candidate autoimmune disease susceptibility genes are those that encode CTLA4 and inducible costimulator (ICOS), immunoregulatory proteins. Associations of CTLA4 polymorphisms with various autoimmune diseases have been reported, but for rheumatoid arthritis (RA) and primary biliary cirrhosis (PBC), the association data are inconsistent and have largely excluded analysis of polymorphisms in the ICOS gene adjacent to CTLA4. We undertook this study to examine whether CTLA4 and ICOS influence RA and PBC susceptibility by testing CTLA4/ICOS polymorphisms for association with these diseases in Canadian subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:AmosChristopher ICI,
pubmed-author:BykerkVivianV,
pubmed-author:ColtescuCatalinaC,
pubmed-author:HeathcoteE JennyEJ,
pubmed-author:HirschfieldGideon MGM,
pubmed-author:KeystoneEdward CEC,
pubmed-author:LiuXiangdongX,
pubmed-author:LuYueY,
pubmed-author:MosherDianneD,
pubmed-author:NewmanWilliam GWG,
pubmed-author:SiminovitchKatherine AKA,
pubmed-author:WalkerErin JEJ,
pubmed-author:WangKeshengK,
pubmed-author:WinSS,
pubmed-author:XuChunC
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
931-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19333938-Adult,
pubmed-meshheading:19333938-Aged,
pubmed-meshheading:19333938-Alleles,
pubmed-meshheading:19333938-Antigens, CD,
pubmed-meshheading:19333938-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:19333938-Arthritis, Rheumatoid,
pubmed-meshheading:19333938-CTLA-4 Antigen,
pubmed-meshheading:19333938-Canada,
pubmed-meshheading:19333938-Female,
pubmed-meshheading:19333938-Genetic Predisposition to Disease,
pubmed-meshheading:19333938-Genetic Variation,
pubmed-meshheading:19333938-Haplotypes,
pubmed-meshheading:19333938-Humans,
pubmed-meshheading:19333938-Inducible T-Cell Co-Stimulator Protein,
pubmed-meshheading:19333938-Linkage Disequilibrium,
pubmed-meshheading:19333938-Liver Cirrhosis, Biliary,
pubmed-meshheading:19333938-Male,
pubmed-meshheading:19333938-Middle Aged,
pubmed-meshheading:19333938-Polymorphism, Genetic,
pubmed-meshheading:19333938-Risk Factors
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pubmed:year |
2009
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pubmed:articleTitle |
CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population.
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pubmed:affiliation |
University of Toronto, Toronto General Hospital, and Mount Sinai Hospital, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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