|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0016059,
umls-concept:C0030705,
umls-concept:C0036421,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205217,
umls-concept:C0214743,
umls-concept:C0332281,
umls-concept:C0441889,
umls-concept:C1123023,
umls-concept:C1299351,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2009-4-7
|
|
pubmed:abstractText |
T lymphocytes play an important role in systemic sclerosis (SSc), a connective tissue disease characterized by inflammation, fibrosis, and vascular damage. While their precise role and antigen specificity are unclear, T cell-derived cytokines likely contribute to the induction of fibrosis. The aim of this study was to establish the role of cytokine dysregulation by T cells in the pathogenesis of SSc.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0004-3591
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
60
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1119-28
|
|
pubmed:meshHeading |
pubmed-meshheading:19333920-Adult,
pubmed-meshheading:19333920-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19333920-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19333920-Cells, Cultured,
pubmed-meshheading:19333920-Female,
pubmed-meshheading:19333920-Fibrosis,
pubmed-meshheading:19333920-Flow Cytometry,
pubmed-meshheading:19333920-Humans,
pubmed-meshheading:19333920-Immunophenotyping,
pubmed-meshheading:19333920-Interleukin-13,
pubmed-meshheading:19333920-Male,
pubmed-meshheading:19333920-Middle Aged,
pubmed-meshheading:19333920-Scleroderma, Systemic,
pubmed-meshheading:19333920-Skin
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis.
|
|
pubmed:affiliation |
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. paf23@pitt.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
