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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-4-29
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pubmed:abstractText |
The blood-brain barrier (BBB) is the main obstacle to cell therapy for neurologic disorders such as amyotrophic lateral sclerosis (ALS). Intrathecal injection is a potential method for cell transplantation because it would bypass the BBB. We investigated the effects of human marrow stromal cells (hMSC) delivered through cerebrospinal fluid (CSF) in a transgenic mouse model of ALS.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1477-2566
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-306
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pubmed:dateRevised |
2010-1-11
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pubmed:meshHeading |
pubmed-meshheading:19333801-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:19333801-Animals,
pubmed-meshheading:19333801-Blood-Brain Barrier,
pubmed-meshheading:19333801-Bone Marrow Transplantation,
pubmed-meshheading:19333801-Cell Count,
pubmed-meshheading:19333801-Cerebrospinal Fluid,
pubmed-meshheading:19333801-Disease Models, Animal,
pubmed-meshheading:19333801-Humans,
pubmed-meshheading:19333801-Injections, Spinal,
pubmed-meshheading:19333801-Mice,
pubmed-meshheading:19333801-Mice, Transgenic,
pubmed-meshheading:19333801-Motor Activity,
pubmed-meshheading:19333801-Motor Neurons,
pubmed-meshheading:19333801-Spinal Cord,
pubmed-meshheading:19333801-Stromal Cells,
pubmed-meshheading:19333801-Superoxide Dismutase,
pubmed-meshheading:19333801-Weight Loss
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pubmed:year |
2009
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pubmed:articleTitle |
Multiple administrations of human marrow stromal cells through cerebrospinal fluid prolong survival in a transgenic mouse model of amyotrophic lateral sclerosis.
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pubmed:affiliation |
Department of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, [corrected] PR China. chengzhang100@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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