rdf:type |
|
lifeskim:mentions |
umls-concept:C0020616,
umls-concept:C0021853,
umls-concept:C0554249,
umls-concept:C0949790,
umls-concept:C1052150,
umls-concept:C1258160,
umls-concept:C1299007,
umls-concept:C1442734,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C2267008,
umls-concept:C2752151,
umls-concept:C2756986,
umls-concept:C2828366
|
pubmed:issue |
9
|
pubmed:dateCreated |
2009-4-17
|
pubmed:abstractText |
Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4-9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal alpha-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal alpha-glucosidase inhibitory potential.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1464-3405
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
1
|
pubmed:volume |
19
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2562-5
|
pubmed:meshHeading |
pubmed-meshheading:19332371-Animals,
pubmed-meshheading:19332371-Chemistry, Pharmaceutical,
pubmed-meshheading:19332371-Drug Design,
pubmed-meshheading:19332371-Enzyme Inhibitors,
pubmed-meshheading:19332371-Hypoglycemic Agents,
pubmed-meshheading:19332371-Magnetic Resonance Spectroscopy,
pubmed-meshheading:19332371-Male,
pubmed-meshheading:19332371-Mass Spectrometry,
pubmed-meshheading:19332371-Phytotherapy,
pubmed-meshheading:19332371-Plant Extracts,
pubmed-meshheading:19332371-Rats,
pubmed-meshheading:19332371-Rats, Wistar,
pubmed-meshheading:19332371-Rhizome,
pubmed-meshheading:19332371-Zingiberaceae,
pubmed-meshheading:19332371-alpha-Glucosidases
|
pubmed:year |
2009
|
pubmed:articleTitle |
New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes.
|
pubmed:affiliation |
Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 607, India.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|