Source:http://linkedlifedata.com/resource/pubmed/id/19332265
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2009-3-31
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pubmed:abstractText |
Pulmonary arterial hypertension (PAH) is a rare, lethal disease associated with single gene disorders, connective tissue disease, exposures to anorexigens, and often, idiopathic etiology. Genes can modify the risk of PAH: (1) monogenic disorders associated with PAH are incompletely penetrant, and (2) not all patients with associated conditions at increased risk for PAH develop the disease. The renin angiotensin aldosterone system (RAAS) provides a set of candidate genes that could modulate pulmonary vascular disease similar to its effects on renal and peripheral vasculature.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1557-3117
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
373-9
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pubmed:meshHeading |
pubmed-meshheading:19332265-Adolescent,
pubmed-meshheading:19332265-Adult,
pubmed-meshheading:19332265-Age of Onset,
pubmed-meshheading:19332265-Aged,
pubmed-meshheading:19332265-Aldosterone Synthase,
pubmed-meshheading:19332265-Chymases,
pubmed-meshheading:19332265-Connective Tissue Diseases,
pubmed-meshheading:19332265-DNA Primers,
pubmed-meshheading:19332265-Female,
pubmed-meshheading:19332265-Genotype,
pubmed-meshheading:19332265-Humans,
pubmed-meshheading:19332265-Hypertension, Pulmonary,
pubmed-meshheading:19332265-Male,
pubmed-meshheading:19332265-Middle Aged,
pubmed-meshheading:19332265-Polymorphism, Genetic,
pubmed-meshheading:19332265-Receptor, Angiotensin, Type 1,
pubmed-meshheading:19332265-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension.
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pubmed:affiliation |
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA. wkc15@columbia.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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