Linked Life Data

19332107

Source:http://linkedlifedata.com/resource/pubmed/id/19332107

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-5-11
pubmed:abstractText
In the CNS, juxtanodin (JN) is an actin-binding oligodendroglial protein that functions to promote differentiation of the host cells during postnatal development. In other tissues, JN expression and function remain unknown. We surveyed rat peripheral nerve, skeletal muscle and various epithelial tissues using immunoblotting and light-microscopic immunohistochemistry, and found prominent JN expression only in the olfactory epithelium (OE). Confocal and immunoelectron microscopy further revealed specific JN expression in the glia-like sustentacular cells and in the ductal cells of Bowman's glands. JN immunoreactivity was especially prominent in sustentacular cell apices extending superficially from the zone of terminal webs and associated adherens junctions, through the zone of tight junctions, to the roots of sustentacular microvilli. Moderate JN was also found in the supranuclear regions of sustentacular cells, whereas distal parts of sustentacular microvilli were devoid of JN. Distribution of JN in the OE differed from that of class III beta-tubulin or nestin, but partially overlapped with a zone of intense F-actin staining near the OE mucous surface. Together these results identify JN as a marker protein for OE sustentacular cells, and support the glia-like nature of OE sustentacular cells. Functionally, JN in the OE might help in the molecular specialization of distinct compartments of olfactory receptor neurons (ORNs), in the interaction of sustentacular cells with ORNs, and/or in maturation/maintenance of sustentacular cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1873-7544
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-58
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Juxtanodin in the rat olfactory epithelium: specific expression in sustentacular cells and preferential subcellular positioning at the apical junctional belt.
pubmed:affiliation
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Block MD10, 4 Medical Drive, Singapore 117597.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't