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rdf:type |
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lifeskim:mentions |
umls-concept:C0001962,
umls-concept:C0034804,
umls-concept:C0085862,
umls-concept:C0596402,
umls-concept:C0599956,
umls-concept:C0996953,
umls-concept:C1299583,
umls-concept:C1512505,
umls-concept:C1549571,
umls-concept:C1555707,
umls-concept:C1608386,
umls-concept:C1705851,
umls-concept:C2752151,
umls-concept:C2828366
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pubmed:issue |
2
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pubmed:dateCreated |
2009-3-27
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pubmed:abstractText |
Motherwort has been used as medicinal herb for many years in both China and Europe. In particular, Chinese motherwort has been commonly used to treat disorders of mammary gland in Chinese traditional medicine (TCM). Chinese motherwort aqueous extract (MAE)was previously reported to have anti-cancer activity in breast cancer cells with low potency (IC50s in a range of 8-40 mg/mL). However, treatment of motherwort ethanol extract in vivo markedly suppressed the development of uterine adenomyosis and mammary cancers in mice. Therefore, anti-cancer activity of Chinese motherwort, especially in a form of ethanol extract, needs to be confirmed further at cellular level.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1872-7573
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
234-9
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pubmed:meshHeading |
pubmed-meshheading:19330917-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:19330917-Apoptosis,
pubmed-meshheading:19330917-Breast Neoplasms,
pubmed-meshheading:19330917-Cell Cycle,
pubmed-meshheading:19330917-Cell Line, Tumor,
pubmed-meshheading:19330917-Cell Proliferation,
pubmed-meshheading:19330917-Drugs, Chinese Herbal,
pubmed-meshheading:19330917-Humans,
pubmed-meshheading:19330917-Leonurus,
pubmed-meshheading:19330917-Necrosis,
pubmed-meshheading:19330917-Phytotherapy,
pubmed-meshheading:19330917-Plant Components, Aerial,
pubmed-meshheading:19330917-Plant Extracts,
pubmed-meshheading:19330917-Receptors, Estrogen
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pubmed:year |
2009
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pubmed:articleTitle |
Cytotoxicity of Chinese motherwort (YiMuCao) aqueous ethanol extract is non-apoptotic and estrogen receptor independent on human breast cancer cells.
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pubmed:affiliation |
Department of General Dentistry, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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