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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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pubmed:dateCreated |
2009-8-11
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|
pubmed:abstractText |
Recent progress in chemotherapy with platinum agents has improved clinical outcome in colorectal cancer (CRC), but there are no useful markers to predict the efficacy of such agents. DNA polymerase beta (POLB) mediates the efficacy of chemotherapy through DNA repair machinery. We analyzed the significance of POLB expression in CRC chemotherapy and its potential as a prognostic indicator.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
|
|
pubmed:issn |
1096-9098
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
261-6
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pubmed:meshHeading |
pubmed-meshheading:19330779-Aged,
pubmed-meshheading:19330779-Antineoplastic Agents,
pubmed-meshheading:19330779-Cell Line, Tumor,
pubmed-meshheading:19330779-Cisplatin,
pubmed-meshheading:19330779-Colorectal Neoplasms,
pubmed-meshheading:19330779-DNA Polymerase beta,
pubmed-meshheading:19330779-Drug Resistance, Neoplasm,
pubmed-meshheading:19330779-Female,
pubmed-meshheading:19330779-Gene Silencing,
pubmed-meshheading:19330779-Genetic Markers,
pubmed-meshheading:19330779-Humans,
pubmed-meshheading:19330779-Immunohistochemistry,
pubmed-meshheading:19330779-Male,
pubmed-meshheading:19330779-Middle Aged,
pubmed-meshheading:19330779-Neoplasm Metastasis,
pubmed-meshheading:19330779-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19330779-Organoplatinum Compounds,
pubmed-meshheading:19330779-Prognosis,
pubmed-meshheading:19330779-RNA, Messenger,
pubmed-meshheading:19330779-RNA, Small Interfering,
pubmed-meshheading:19330779-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19330779-Survival Analysis
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pubmed:year |
2009
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pubmed:articleTitle |
A platinum agent resistance gene, POLB, is a prognostic indicator in colorectal cancer.
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pubmed:affiliation |
Department of Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu 874-0838, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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