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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-28
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pubmed:abstractText |
A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-10815882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-11923519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-11990853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-11994741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-12908552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-14517555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-14996728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-16142232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-16912171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-16959974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-17344846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-17851543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-18413742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330028-8654922
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1546-1718
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pubmed:author |
pubmed-author:AgrawalNeena SNS,
pubmed-author:BanisterCarolyn ECE,
pubmed-author:BrodyLawrence CLC,
pubmed-author:BuckhaultsPhillipP,
pubmed-author:BurrellAllison SAS,
pubmed-author:CroninJulia CJC,
pubmed-author:DavisSeanS,
pubmed-author:FetschPatriciaP,
pubmed-author:FilieArmando CAC,
pubmed-author:Hoogstraten-MillerShelleyS,
pubmed-author:HowardJason DJD,
pubmed-author:LinJimmy CJC,
pubmed-author:MolinoloAlfredo AAA,
pubmed-author:O'ConnellMichael PMP,
pubmed-author:PalavalliLavanya HLH,
pubmed-author:Porter-GillPatriciaP,
pubmed-author:PrickettTodd DTD,
pubmed-author:RosenbergSteven ASA,
pubmed-author:SamuelsYardenaY,
pubmed-author:WangChenweiC,
pubmed-author:WeeraratnaAshani TAT,
pubmed-author:WeiXiaomuX,
pubmed-author:WestbroekWendyW,
pubmed-author:WunderlichJohn RJR
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
518-20
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pubmed:dateRevised |
2011-9-28
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
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pubmed:affiliation |
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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