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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-4-17
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pubmed:abstractText |
The prevention of aggrecan (a key component of cartilage) cleavage via the inhibition of aggrecanase-1 may provide a unique opportunity to stop the progression of cartilage degradation in osteoarthritis. The evaluation of a series of biphenylsulfonamides resulted in the identification of the ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides analogs (19-21 and 24) with improved Agg-1 inhibition and MMP-2, MMP-13 activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:DaronH HHH,
pubmed-author:FeyfantEricE,
pubmed-author:GeorgiadisKaty EKE,
pubmed-author:HopperDarrin WDW,
pubmed-author:HuYonghanY,
pubmed-author:IpekManusM,
pubmed-author:KeohanCristin CCC,
pubmed-author:MajumdarManas KMK,
pubmed-author:MorrisElisabeth AEA,
pubmed-author:ReifenbergEricaE,
pubmed-author:SabatiniJoshuaJ,
pubmed-author:SheldonRichard TRT,
pubmed-author:SkotnickiJerauldJ,
pubmed-author:SumPhaik-EngPE,
pubmed-author:ThomasonJenniferJ,
pubmed-author:VeraMatthew DMD,
pubmed-author:WangQinQ,
pubmed-author:XiangJason SJS
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2487-91
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pubmed:meshHeading |
pubmed-meshheading:19329309-ADAM Proteins,
pubmed-meshheading:19329309-Cartilage,
pubmed-meshheading:19329309-Chemistry, Pharmaceutical,
pubmed-meshheading:19329309-Drug Design,
pubmed-meshheading:19329309-Humans,
pubmed-meshheading:19329309-Inhibitory Concentration 50,
pubmed-meshheading:19329309-Matrix Metalloproteinase 13,
pubmed-meshheading:19329309-Matrix Metalloproteinase 2,
pubmed-meshheading:19329309-Models, Chemical,
pubmed-meshheading:19329309-Molecular Conformation,
pubmed-meshheading:19329309-Osteoarthritis,
pubmed-meshheading:19329309-Procollagen N-Endopeptidase,
pubmed-meshheading:19329309-Proteoglycans,
pubmed-meshheading:19329309-Sulfonamides
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pubmed:year |
2009
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pubmed:articleTitle |
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.
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pubmed:affiliation |
Department of Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA.
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pubmed:publicationType |
Journal Article
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