Linked Life Data

19328839

Source:http://linkedlifedata.com/resource/pubmed/id/19328839

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-6-1
pubmed:abstractText
In the present study, we asked whether multiple intrathecal injections of deltorphin II, a selective delta opioid receptor (DOPR) agonist, induced DOPR tolerance in three behavioral assays. Unilateral inflammation caused by complete Freund's adjuvant (CFA) injection into the rat or mouse hind paw (CFA model) induced thermal hyperalgesic response that was transiently and dose-dependently reduced by intrathecal administration of deltorphin II or morphine. In both rodent species, the effect of deltorphin II was not modified by a single prior administration of deltorphin II, suggesting an absence of acute tolerance in this paradigm. Repeated administration of intrathecal deltorphin II or s.c. SB-235863 (five consecutive injections over 60 h) also failed to impair the antihyperalgesic response to delta opioid receptor agonist, whereas repeated intrathecal or s.c. injections of morphine induced a significant decrease in the subsequent thermal antihyperalgesic response to morphine. In mice, deltorphin II also induced a rapid, transient motor incoordination/ataxia-like behavior as tested with the accelerating rotarod. In contrast to the antihyperalgesic responses, tolerance to the motoric effect of deltorphin II was evident in mice previously exposed to multiple intrathecal agonist injections, but not multiple saline administrations. Using the tail flick antinociceptive test, we found that DOPR-mediated analgesia was significantly reduced by repeated exposure to deltorphin II. Altogether, these observations suggest that repeated injections of DOPR agonists induce differential tolerance effects on antihyperalgesic, antinociceptive, and motor incoordination/ataxia-like behaviors related to DOPR activation by deltorphin II.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1873-7544
pubmed:author
pubmed:issnType
Electronic
pubmed:day
30
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-91
pubmed:meshHeading
pubmed-meshheading:19328839-Administration, Cutaneous, pubmed-meshheading:19328839-Animals, pubmed-meshheading:19328839-Arthritis, Experimental, pubmed-meshheading:19328839-Dose-Response Relationship, Drug, pubmed-meshheading:19328839-Drug Tolerance, pubmed-meshheading:19328839-Freund's Adjuvant, pubmed-meshheading:19328839-Hot Temperature, pubmed-meshheading:19328839-Hyperalgesia, pubmed-meshheading:19328839-Injections, Spinal, pubmed-meshheading:19328839-Male, pubmed-meshheading:19328839-Mice, pubmed-meshheading:19328839-Mice, Inbred C57BL, pubmed-meshheading:19328839-Morphine, pubmed-meshheading:19328839-Morphine Derivatives, pubmed-meshheading:19328839-Motor Activity, pubmed-meshheading:19328839-Oligopeptides, pubmed-meshheading:19328839-Pain, pubmed-meshheading:19328839-Rats, pubmed-meshheading:19328839-Rats, Sprague-Dawley, pubmed-meshheading:19328839-Receptors, Opioid, delta
pubmed:year
2009
pubmed:articleTitle
Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodents.
pubmed:affiliation
Department of Physiology and Biophysics, Université de Sherbrooke, Faculty of Medicine, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural