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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-6-30
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pubmed:abstractText |
The internal anal sphincter (IAS) is a specialized circular smooth muscle that maintains rectoanal continence. In vitro models are needed to study the pathophysiology of human IAS disorders. We bioengineered sphincteric rings from human IAS smooth muscle cells (SMC) and investigated their response to cholinergic stimulation as well as investigated whether protein kinase C (PKC) and Rho kinase signaling pathways remain functional.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19328796-Acetylcholine,
pubmed-meshheading:19328796-Anal Canal,
pubmed-meshheading:19328796-Calmodulin-Binding Proteins,
pubmed-meshheading:19328796-Caveolae,
pubmed-meshheading:19328796-Cells, Cultured,
pubmed-meshheading:19328796-Dose-Response Relationship, Drug,
pubmed-meshheading:19328796-Enzyme Activators,
pubmed-meshheading:19328796-Feasibility Studies,
pubmed-meshheading:19328796-Fibrin,
pubmed-meshheading:19328796-HSP27 Heat-Shock Proteins,
pubmed-meshheading:19328796-Humans,
pubmed-meshheading:19328796-Muscle Contraction,
pubmed-meshheading:19328796-Muscle Relaxation,
pubmed-meshheading:19328796-Myocytes, Smooth Muscle,
pubmed-meshheading:19328796-Protein Kinase C-alpha,
pubmed-meshheading:19328796-Protein Kinase Inhibitors,
pubmed-meshheading:19328796-Signal Transduction,
pubmed-meshheading:19328796-Time Factors,
pubmed-meshheading:19328796-Tissue Engineering,
pubmed-meshheading:19328796-rho-Associated Kinases,
pubmed-meshheading:19328796-rhoA GTP-Binding Protein
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pubmed:year |
2009
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pubmed:articleTitle |
Bioengineered internal anal sphincter derived from isolated human internal anal sphincter smooth muscle cells.
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pubmed:affiliation |
Department of Pediatrics-Gastroenterology University of Michigan, Ann Arbor, Michigan 48109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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