Linked Life Data

19328217

Source:http://linkedlifedata.com/resource/pubmed/id/19328217

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-5-8
pubmed:abstractText
Wolframin gene polymorphisms, including the H611R polymorphism, are reportedly associated with mood disorders and psychiatric hospitalization, but there is disagreement about the association of this specific variant with suicidality and impulsive traits. This study tested the association of the H611R polymorphism with mood disorders, suicidal behavior, and aggressive-impulsive traits. Two hundred and one subjects with mood disorders and 113 healthy volunteers were genotyped for the H611R polymorphism and underwent structured interviews for diagnosis and clinical ratings. All were Caucasians. The H611R polymorphism was associated with mood disorders but not suicidal behavior, aggressive/impulsive traits or suicidality in first-degree relatives. The HR heterozygote genotype was more frequent in mood disorder (chi(2)=7.505; df=2; p=.023). If this finding will be replicated, the H611R polymorphism may be a possible marker for mood disorders in a psychiatric population, and not just in relatives of Wolfram syndrome probands.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1878-4216
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
707-10
pubmed:dateRevised
2011-10-19
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Wolframin gene H611R polymorphism: no direct association with suicidal behavior but possible link to mood disorders.
pubmed:affiliation
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Geha MHC, Israel. Zalsman@post.tau.ac.il
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural