| pubmed-article:19326941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19326941 | lifeskim:mentions | umls-concept:C0538091 | lld:lifeskim |
| pubmed-article:19326941 | lifeskim:mentions | umls-concept:C0022115 | lld:lifeskim |
| pubmed-article:19326941 | lifeskim:mentions | umls-concept:C0038760 | lld:lifeskim |
| pubmed-article:19326941 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19326941 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:19326941 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19326941 | lifeskim:mentions | umls-concept:C1328819 | lld:lifeskim |
| pubmed-article:19326941 | lifeskim:mentions | umls-concept:C0000901 | lld:lifeskim |
| pubmed-article:19326941 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:19326941 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:19326941 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:19326941 | pubmed:dateCreated | 2009-4-16 | lld:pubmed |
| pubmed-article:19326941 | pubmed:abstractText | A key step in the onset of Huntington's disease is the caspase-6 mediated cleavage of the protein huntingtin into toxic fragments. Therefore, the inhibition of caspase-6 has been identified as a target for therapeutic drug development for the treatment of this disease. In this study, a series of isatin sulfonamide Michael acceptors having a high nanomolar potency for inhibiting caspase-6 and increased selectivity for caspase-6 versus caspase-3 inhibition is reported. | lld:pubmed |
| pubmed-article:19326941 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19326941 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19326941 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19326941 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19326941 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19326941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19326941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19326941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19326941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19326941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19326941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19326941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19326941 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19326941 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:19326941 | pubmed:author | pubmed-author:MachRobert... | lld:pubmed |
| pubmed-article:19326941 | pubmed:author | pubmed-author:ZhouDongD | lld:pubmed |
| pubmed-article:19326941 | pubmed:author | pubmed-author:ChuYunxiangY | lld:pubmed |
| pubmed-article:19326941 | pubmed:author | pubmed-author:ChuWenhuaW | lld:pubmed |
| pubmed-article:19326941 | pubmed:author | pubmed-author:RothfussJusti... | lld:pubmed |
| pubmed-article:19326941 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19326941 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:19326941 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:19326941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19326941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19326941 | pubmed:pagination | 2188-91 | lld:pubmed |
| pubmed-article:19326941 | pubmed:meshHeading | pubmed-meshheading:19326941... | lld:pubmed |
| pubmed-article:19326941 | pubmed:meshHeading | pubmed-meshheading:19326941... | lld:pubmed |
| pubmed-article:19326941 | pubmed:meshHeading | pubmed-meshheading:19326941... | lld:pubmed |
| pubmed-article:19326941 | pubmed:meshHeading | pubmed-meshheading:19326941... | lld:pubmed |
| pubmed-article:19326941 | pubmed:meshHeading | pubmed-meshheading:19326941... | lld:pubmed |
| pubmed-article:19326941 | pubmed:meshHeading | pubmed-meshheading:19326941... | lld:pubmed |
| pubmed-article:19326941 | pubmed:meshHeading | pubmed-meshheading:19326941... | lld:pubmed |
| pubmed-article:19326941 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19326941 | pubmed:articleTitle | Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. | lld:pubmed |
| pubmed-article:19326941 | pubmed:affiliation | Department of Radiology, Washington University School of Medicine, 510 S. Kingshighway Boulevard, St. Louis, Missouri 63110, USA. | lld:pubmed |
| pubmed-article:19326941 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19326941 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19326941 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19326941 | lld:chembl |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19326941 | lld:pubmed |
