|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003483,
umls-concept:C0003591,
umls-concept:C0012359,
umls-concept:C0018270,
umls-concept:C0026809,
umls-concept:C0184512,
umls-concept:C0330390,
umls-concept:C0332461,
umls-concept:C0678594,
umls-concept:C1292733,
umls-concept:C1549649,
umls-concept:C2349209
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2009-8-20
|
|
pubmed:abstractText |
Impairment of transforming growth factor (TGF)-beta1 signaling accelerates atherosclerosis in experimental mice. However, it is uncertain whether increased TGF-beta1 expression would retard atherosclerosis. The role of TGF-beta1 in aneurysm formation is also controversial. We tested whether overexpression of active TGF-beta1 in hyperlipidemic mice affects atherogenesis and aortic dilation.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1524-4636
|
|
pubmed:author |
pubmed-author:AtanasioSS,
pubmed-author:DichekDavid ADA,
pubmed-author:DichekHelén LHL,
pubmed-author:DuLiangL,
pubmed-author:EdwardsDylan RDR,
pubmed-author:FrutkinAndrew DAD,
pubmed-author:HuJie HongJH,
pubmed-author:MarieJulien CJC,
pubmed-author:MinterDanielD,
pubmed-author:Nieves-CintrónMadelineM,
pubmed-author:OtsukaGoroG,
pubmed-author:PenningtonCaroline JCJ,
pubmed-author:PreuschMichaelM,
pubmed-author:SestiCasildeC,
pubmed-author:Stempien-OteroAprilA
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
29
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1251-7
|
|
pubmed:dateRevised |
2010-12-3
|
|
pubmed:meshHeading |
pubmed-meshheading:19325140-Aneurysm, False,
pubmed-meshheading:19325140-Animals,
pubmed-meshheading:19325140-Aortic Aneurysm,
pubmed-meshheading:19325140-Apolipoproteins E,
pubmed-meshheading:19325140-Atherosclerosis,
pubmed-meshheading:19325140-Collagen,
pubmed-meshheading:19325140-Dilatation, Pathologic,
pubmed-meshheading:19325140-Disease Models, Animal,
pubmed-meshheading:19325140-Female,
pubmed-meshheading:19325140-Gene Expression Regulation,
pubmed-meshheading:19325140-Hyperlipidemias,
pubmed-meshheading:19325140-Lipid Metabolism,
pubmed-meshheading:19325140-Mice,
pubmed-meshheading:19325140-Mice, Inbred C57BL,
pubmed-meshheading:19325140-Mice, Knockout,
pubmed-meshheading:19325140-Mice, Transgenic,
pubmed-meshheading:19325140-Myocardium,
pubmed-meshheading:19325140-Signal Transduction,
pubmed-meshheading:19325140-T-Lymphocytes,
pubmed-meshheading:19325140-Time Factors,
pubmed-meshheading:19325140-Transforming Growth Factor beta1
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.
|
|
pubmed:affiliation |
Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195-7710, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
