|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2009-4-6
|
|
pubmed:abstractText |
In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-10986805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-11410943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-12476325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-13638508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-13680525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-15083261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-15169693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-15322418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-16084860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-16818866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-16818867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-16988657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-17053149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-17536209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-17894418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-18061146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-18412099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-18465373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-2768151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-3326459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-6080235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-7674893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-7711769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-8139448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-9183141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-9204677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19324536-9582996
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0165-1781
|
|
pubmed:author |
pubmed-author:ArnoldPaul DanielPD,
pubmed-author:BurroughsElizaE,
pubmed-author:EasterPhillip CPC,
pubmed-author:HannaGregory LGL,
pubmed-author:KennedyJames LJL,
pubmed-author:MacmasterFrank PFP,
pubmed-author:MirzaYoushaY,
pubmed-author:RichterMargaret AMA,
pubmed-author:RoseMichelleM,
pubmed-author:RosenbergDavid RDR,
pubmed-author:SicardTriciaT
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
172
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
136-9
|
|
pubmed:dateRevised |
2011-4-1
|
|
pubmed:meshHeading |
pubmed-meshheading:19324536-Adolescent,
pubmed-meshheading:19324536-Age Factors,
pubmed-meshheading:19324536-Brain,
pubmed-meshheading:19324536-Child,
pubmed-meshheading:19324536-Female,
pubmed-meshheading:19324536-Genetic Variation,
pubmed-meshheading:19324536-Genotype,
pubmed-meshheading:19324536-Glutamic Acid,
pubmed-meshheading:19324536-Gyrus Cinguli,
pubmed-meshheading:19324536-Humans,
pubmed-meshheading:19324536-Magnetic Resonance Spectroscopy,
pubmed-meshheading:19324536-Male,
pubmed-meshheading:19324536-Obsessive-Compulsive Disorder,
pubmed-meshheading:19324536-Occipital Lobe,
pubmed-meshheading:19324536-Polymorphism, Genetic,
pubmed-meshheading:19324536-Receptors, N-Methyl-D-Aspartate
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder.
|
|
pubmed:affiliation |
Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8. paul.arnold@sickkids.ca
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
