|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007131,
umls-concept:C0007634,
umls-concept:C0008838,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0140145,
umls-concept:C0332281,
umls-concept:C0441655,
umls-concept:C0599894,
umls-concept:C0683598,
umls-concept:C1332102,
umls-concept:C1514559,
umls-concept:C1521840,
umls-concept:C2349975
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2009-11-9
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|
pubmed:abstractText |
Apurinic/apyrimidinic endonuclease (APE1), a bifunctional AP endonuclease/redox factor, is important in DNA repair and redox signaling, may be associated with chemoresistance. In this study, we first investigated APE1 expression and its correlation with cisplatin resistance and prognosis in non-small cell lung cancer (NSCLC) patients. Then, we investigated the effect of chimeric adenoviral vector Ad5/F35 carrying human APE1 siRNA (Ad5/F35-APE1 siRNA) on the sensitivity of cisplatin in A549 human lung adenocarcinoma cells.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1872-8332
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:volume |
66
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
298-304
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|
pubmed:meshHeading |
pubmed-meshheading:19324449-Adenoviridae,
pubmed-meshheading:19324449-Adult,
pubmed-meshheading:19324449-Aged,
pubmed-meshheading:19324449-Apoptosis,
pubmed-meshheading:19324449-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:19324449-Cell Line, Tumor,
pubmed-meshheading:19324449-Cisplatin,
pubmed-meshheading:19324449-DNA-(Apurinic or Apyrimidinic Site) Lyase,
pubmed-meshheading:19324449-Disease Progression,
pubmed-meshheading:19324449-Drug Resistance, Neoplasm,
pubmed-meshheading:19324449-Female,
pubmed-meshheading:19324449-Humans,
pubmed-meshheading:19324449-Lung Neoplasms,
pubmed-meshheading:19324449-Male,
pubmed-meshheading:19324449-Middle Aged,
pubmed-meshheading:19324449-Prognosis,
pubmed-meshheading:19324449-RNA, Small Interfering,
pubmed-meshheading:19324449-Transduction, Genetic
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|
pubmed:year |
2009
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pubmed:articleTitle |
APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells.
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pubmed:affiliation |
Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China. dongwang64@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
