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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0021390,
umls-concept:C0205263,
umls-concept:C0441655,
umls-concept:C0962190,
umls-concept:C1149231,
umls-concept:C1155064,
umls-concept:C1334107,
umls-concept:C1367171,
umls-concept:C1416406,
umls-concept:C1423038,
umls-concept:C1831593,
umls-concept:C2349975,
umls-concept:C2936411
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pubmed:issue |
8
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pubmed:dateCreated |
2009-7-21
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pubmed:abstractText |
Interleukin-21 (IL-21) is involved in T and NK cell activation and effector response and promotes Th17 cell differentiation. Here we investigated IL-21 receptor (IL-21R) expression in inflamed mucosa of inflammatory bowel disease (IBD) and evaluated its role in the induction of NK cell cytotoxicity and activation as well as Th17 differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1536-4844
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1133-44
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pubmed:meshHeading |
pubmed-meshheading:19322899-Adolescent,
pubmed-meshheading:19322899-Adult,
pubmed-meshheading:19322899-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19322899-Cell Differentiation,
pubmed-meshheading:19322899-Cytokines,
pubmed-meshheading:19322899-Cytotoxicity, Immunologic,
pubmed-meshheading:19322899-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19322899-Female,
pubmed-meshheading:19322899-Flow Cytometry,
pubmed-meshheading:19322899-Humans,
pubmed-meshheading:19322899-Immunoenzyme Techniques,
pubmed-meshheading:19322899-Inflammatory Bowel Diseases,
pubmed-meshheading:19322899-Interferon-gamma,
pubmed-meshheading:19322899-Interleukin-17,
pubmed-meshheading:19322899-Interleukins,
pubmed-meshheading:19322899-Intestinal Mucosa,
pubmed-meshheading:19322899-Killer Cells, Natural,
pubmed-meshheading:19322899-Lymphocyte Activation,
pubmed-meshheading:19322899-Male,
pubmed-meshheading:19322899-Middle Aged,
pubmed-meshheading:19322899-Polymerase Chain Reaction,
pubmed-meshheading:19322899-RNA, Messenger,
pubmed-meshheading:19322899-Receptors, Interleukin-21,
pubmed-meshheading:19322899-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19322899-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:19322899-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19322899-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease.
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pubmed:affiliation |
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. zhanjuliu@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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