| pubmed-article:19322764 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19322764 | lifeskim:mentions | umls-concept:C0003069 | lld:lifeskim |
| pubmed-article:19322764 | lifeskim:mentions | umls-concept:C0043457 | lld:lifeskim |
| pubmed-article:19322764 | lifeskim:mentions | umls-concept:C0027100 | lld:lifeskim |
| pubmed-article:19322764 | lifeskim:mentions | umls-concept:C0949657 | lld:lifeskim |
| pubmed-article:19322764 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19322764 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:19322764 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:19322764 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:19322764 | lifeskim:mentions | umls-concept:C0205374 | lld:lifeskim |
| pubmed-article:19322764 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:19322764 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19322764 | pubmed:dateCreated | 2009-6-3 | lld:pubmed |
| pubmed-article:19322764 | pubmed:abstractText | The zebrafish ventricular myosin heavy chain (vmhc) gene exhibits restricted expression in the ventricle. However, the molecular mechanism underlying this chamber-specific expression is unclear. Here, we exploited both transient and transgenic technologies to dissect the zebrafish vmhc promoter. We demonstrated that a combination of two transient assays in this animal model quickly identified chamber-specific cis-elements, isolating a 2.2 kb fragment upstream from the vmhc gene that can drive ventricle-specific expression. Furthermore, deletion analysis identified multiple cis-elements that exhibited cardiac-specific expression. To achieve chamber specificity, a distal element was required to coordinate with and suppress a proximal enhancer element. Finally, we discovered that Nkx2.5-binding sites (NKE) were essential for this repressive function. In summary, our study of the zebrafish vmhc promoter suggests that ventricle-specific expression is achieved through an inhibitory mechanism that suppresses expression in the atrium. Developmental Dynamics 238:1564-1573, 2009. (c) 2009 Wiley-Liss, Inc. | lld:pubmed |
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| pubmed-article:19322764 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19322764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19322764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19322764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19322764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19322764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19322764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19322764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19322764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19322764 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19322764 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19322764 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19322764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19322764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19322764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19322764 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19322764 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19322764 | pubmed:issn | 1058-8388 | lld:pubmed |
| pubmed-article:19322764 | pubmed:author | pubmed-author:XuXiaoleiX | lld:pubmed |
| pubmed-article:19322764 | pubmed:author | pubmed-author:ZhangRuilinR | lld:pubmed |
| pubmed-article:19322764 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19322764 | pubmed:volume | 238 | lld:pubmed |
| pubmed-article:19322764 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19322764 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19322764 | pubmed:pagination | 1564-73 | lld:pubmed |
| pubmed-article:19322764 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:19322764 | pubmed:meshHeading | pubmed-meshheading:19322764... | lld:pubmed |
| pubmed-article:19322764 | pubmed:meshHeading | pubmed-meshheading:19322764... | lld:pubmed |
| pubmed-article:19322764 | pubmed:meshHeading | pubmed-meshheading:19322764... | lld:pubmed |
| pubmed-article:19322764 | pubmed:meshHeading | pubmed-meshheading:19322764... | lld:pubmed |
| pubmed-article:19322764 | pubmed:meshHeading | pubmed-meshheading:19322764... | lld:pubmed |
| pubmed-article:19322764 | pubmed:meshHeading | pubmed-meshheading:19322764... | lld:pubmed |
| pubmed-article:19322764 | pubmed:meshHeading | pubmed-meshheading:19322764... | lld:pubmed |
| pubmed-article:19322764 | pubmed:meshHeading | pubmed-meshheading:19322764... | lld:pubmed |
| pubmed-article:19322764 | pubmed:meshHeading | pubmed-meshheading:19322764... | lld:pubmed |
| pubmed-article:19322764 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19322764 | pubmed:articleTitle | Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: an inhibitory mechanism of ventricle-specific gene expression. | lld:pubmed |
| pubmed-article:19322764 | pubmed:affiliation | Department of Biochemistry and Molecular Biology/Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. | lld:pubmed |
| pubmed-article:19322764 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19322764 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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