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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0079189,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0205307,
umls-concept:C0333348,
umls-concept:C1123023,
umls-concept:C1149779,
umls-concept:C1517488,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
2009-10-7
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pubmed:abstractText |
The vanin gene family encodes secreted and membrane-bound ectoenzymes that convert pantetheine into pantothenic acid and cysteamine. Recent studies in a mouse colitis model indicated that vanin-1 has proinflammatory activity and suggest that pantetheinases are potential therapeutic targets in inflammatory diseases. In a microarray analysis of epidermal gene expression of psoriasis and atopic dermatitis lesions, we identified vanin-3 as the gene showing the highest differential expression of all annotated genes that we studied (19-fold upregulation in psoriasis). Quantitative real-time PCR analysis confirmed the microarray data on vanin-3 and showed similar induction of vanin-1, but not of vanin-2, in psoriatic epidermis. Immunohistochemistry showed that vanin-3 is expressed in the differentiated epidermal layers. Using submerged and organotypic keratinocyte cultures, we found that vanin-1 and vanin-3 are induced at the mRNA and protein level by psoriasis-associated proinflammatory cytokines (Th17/Th1) but not by Th2 cytokines. We hypothesize that increased levels of pantetheinase activity are part of the inflammatory-regenerative epidermal differentiation program, and may contribute to the phenotype observed in psoriasis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amidohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteamine,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transglutaminases,
http://linkedlifedata.com/resource/pubmed/chemical/VNN2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/VNN3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/pantetheinase
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1523-1747
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2167-74
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19322213-Amidohydrolases,
pubmed-meshheading:19322213-Caspase 3,
pubmed-meshheading:19322213-Cell Adhesion Molecules,
pubmed-meshheading:19322213-Cysteamine,
pubmed-meshheading:19322213-Cytokines,
pubmed-meshheading:19322213-GPI-Linked Proteins,
pubmed-meshheading:19322213-Gene Expression Regulation,
pubmed-meshheading:19322213-Humans,
pubmed-meshheading:19322213-Hydrolases,
pubmed-meshheading:19322213-Keratinocytes,
pubmed-meshheading:19322213-PPAR gamma,
pubmed-meshheading:19322213-Psoriasis,
pubmed-meshheading:19322213-RNA, Messenger,
pubmed-meshheading:19322213-Skin,
pubmed-meshheading:19322213-Transglutaminases
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pubmed:year |
2009
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pubmed:articleTitle |
Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines.
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pubmed:affiliation |
Department of Dermatology and Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
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pubmed:publicationType |
Journal Article
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