|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2009-8-12
|
|
pubmed:abstractText |
Cytopenia represents a significant complication after chemotherapy, irradiation before bone marrow (BM) transplantation or as a therapy for cancer. The mechanisms that determine the pace of BM recovery are not fully understood. During the recovery phase after chemotherapy or irradiation, the signals for retention of white blood cells within the BM increase significantly. This leads to a delay in the release of WBC, which can be overcome by targeting the CXCR4 axis with the antagonist 4F-benzoyl-TN14003 (T140). The delay in the release of WBC is also accompanied by suppression in the production of progenitor cells and mature cells by the BM stroma. Administration of T140 to mice transplanted with BM cells stimulates the production of all types of progenitors and mature cells, and increases the exit of mature cells to the periphery. Moreover, addition of T140, but not AMD3100, to BM stromal cultures stimulates the production of mature cells and progenitors from all lineages. The unique ability of the CXCR4 antagonist, T140 to stimulate the production and exit of WBC cells may be used as a novel therapeutic approach to overcome cytopenia associated with treatments for cancer and BM transplantation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-fluorobenzoyl-TN-14003,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/Heterocyclic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha4beta1,
http://linkedlifedata.com/resource/pubmed/chemical/JM 3100,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Mmp9 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1476-5551
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1378-88
|
|
pubmed:meshHeading |
pubmed-meshheading:19322207-Animals,
pubmed-meshheading:19322207-Bone Marrow,
pubmed-meshheading:19322207-Cell Division,
pubmed-meshheading:19322207-Coculture Techniques,
pubmed-meshheading:19322207-Colony-Forming Units Assay,
pubmed-meshheading:19322207-Cyclophosphamide,
pubmed-meshheading:19322207-Drug Evaluation, Preclinical,
pubmed-meshheading:19322207-Female,
pubmed-meshheading:19322207-Graft Survival,
pubmed-meshheading:19322207-Hematopoietic Stem Cell Mobilization,
pubmed-meshheading:19322207-Hematopoietic Stem Cells,
pubmed-meshheading:19322207-Heterocyclic Compounds,
pubmed-meshheading:19322207-Integrin alpha4beta1,
pubmed-meshheading:19322207-Matrix Metalloproteinase 9,
pubmed-meshheading:19322207-Mice,
pubmed-meshheading:19322207-Mice, Inbred C57BL,
pubmed-meshheading:19322207-Neutropenia,
pubmed-meshheading:19322207-Peptides,
pubmed-meshheading:19322207-Radiation Chimera,
pubmed-meshheading:19322207-Receptors, CXCR4,
pubmed-meshheading:19322207-Recovery of Function,
pubmed-meshheading:19322207-Specific Pathogen-Free Organisms,
pubmed-meshheading:19322207-Stromal Cells
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation.
|
|
pubmed:affiliation |
Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
