| pubmed-article:19321768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19321768 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:19321768 | lifeskim:mentions | umls-concept:C0028633 | lld:lifeskim |
| pubmed-article:19321768 | lifeskim:mentions | umls-concept:C0107103 | lld:lifeskim |
| pubmed-article:19321768 | lifeskim:mentions | umls-concept:C0574032 | lld:lifeskim |
| pubmed-article:19321768 | lifeskim:mentions | umls-concept:C0220839 | lld:lifeskim |
| pubmed-article:19321768 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:19321768 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:19321768 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:19321768 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:19321768 | pubmed:dateCreated | 2009-3-26 | lld:pubmed |
| pubmed-article:19321768 | pubmed:abstractText | The glutamatergic pathway arising in the dorsomedial prefrontal cortex (dmPFC) and projecting to the nucleus accumbens (NAc) core is a critical component of the reward circuitry that underlies reinstatement to cocaine-seeking behavior. Brain-derived neurotrophic factor (BDNF) is expressed by and modulates PFC-NAc neurons. BDNF infusion into the dmPFC attenuates reinstatement to cocaine-seeking behavior, as well as some cocaine-induced molecular adaptations within the NAc. In the present study, it is demonstrated that a single intra-dmPFC infusion of BDNF prevents cocaine self-administration-induced reduction in basal extracellular glutamate, as well as cocaine prime-induced increases in extracellular glutamate levels within the NAc. These data suggest that intra-PFC BDNF attenuates reinstatement to cocaine-seeking behavior by normalizing cocaine-induced neuroadaptations that alter glutamate neurotransmission within the NAc. | lld:pubmed |
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| pubmed-article:19321768 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19321768 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19321768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19321768 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19321768 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:19321768 | pubmed:author | pubmed-author:KalivasPeter... | lld:pubmed |
| pubmed-article:19321768 | pubmed:author | pubmed-author:McGintyJacque... | lld:pubmed |
| pubmed-article:19321768 | pubmed:author | pubmed-author:BerglindWilli... | lld:pubmed |
| pubmed-article:19321768 | pubmed:author | pubmed-author:LaLumiereRyan... | lld:pubmed |
| pubmed-article:19321768 | pubmed:author | pubmed-author:WhitfieldTimo... | lld:pubmed |
| pubmed-article:19321768 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19321768 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:19321768 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:19321768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19321768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19321768 | pubmed:pagination | 3715-9 | lld:pubmed |
| pubmed-article:19321768 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19321768 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19321768 | pubmed:articleTitle | A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens. | lld:pubmed |
| pubmed-article:19321768 | pubmed:affiliation | Department of Neurosciences and Neurobiology of Addiction Research Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA. | lld:pubmed |
| pubmed-article:19321768 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19321768 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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