19321768

Source:http://linkedlifedata.com/resource/pubmed/id/19321768

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0028633, umls-concept:C0107103, umls-concept:C0205171, umls-concept:C0220839, umls-concept:C0521119, umls-concept:C0574032, umls-concept:C1292733, umls-concept:C1515926
pubmed:issue	12
pubmed:dateCreated	2009-3-26
pubmed:abstractText	The glutamatergic pathway arising in the dorsomedial prefrontal cortex (dmPFC) and projecting to the nucleus accumbens (NAc) core is a critical component of the reward circuitry that underlies reinstatement to cocaine-seeking behavior. Brain-derived neurotrophic factor (BDNF) is expressed by and modulates PFC-NAc neurons. BDNF infusion into the dmPFC attenuates reinstatement to cocaine-seeking behavior, as well as some cocaine-induced molecular adaptations within the NAc. In the present study, it is demonstrated that a single intra-dmPFC infusion of BDNF prevents cocaine self-administration-induced reduction in basal extracellular glutamate, as well as cocaine prime-induced increases in extracellular glutamate levels within the NAc. These data suggest that intra-PFC BDNF attenuates reinstatement to cocaine-seeking behavior by normalizing cocaine-induced neuroadaptations that alter glutamate neurotransmission within the NAc.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/F31 DA018500, http://linkedlifedata.com/resource/pubmed/grant/F31 DA023743, http://linkedlifedata.com/resource/pubmed/grant/F32 DA021460, http://linkedlifedata.com/resource/pubmed/grant/P50 DA015369, http://linkedlifedata.com/resource/pubmed/grant/P50 DA015369-060006, http://linkedlifedata.com/resource/pubmed/grant/T32 DA07288
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-10553907, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-10725920, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-10942857, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-11264540, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-11606653, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-11701755, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-11752112, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-12388621, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-12663747, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-12716962, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-12778052, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-14973246, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-15138757, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-15317862, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-15770106, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-16000629, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-16055761, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-16870745, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-17618281, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-17651427, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-18094234, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-18354020, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-3618773, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-8778304, http://linkedlifedata.com/resource/pubmed/commentcorrection/19321768-9809461
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8102140
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor, http://linkedlifedata.com/resource/pubmed/chemical/Cocaine, http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1529-2401
pubmed:author	pubmed-author:BerglindWilliam JWJ, pubmed-author:KalivasPeter WPW, pubmed-author:LaLumiereRyan TRT, pubmed-author:McGintyJacqueline FJF, pubmed-author:WhitfieldTimothy WTWJr
pubmed:issnType	Electronic
pubmed:day	25
pubmed:volume	29
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3715-9
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:19321768-Animals, pubmed-meshheading:19321768-Brain-Derived Neurotrophic Factor, pubmed-meshheading:19321768-Cocaine, pubmed-meshheading:19321768-Cocaine-Related Disorders, pubmed-meshheading:19321768-Conditioning, Operant, pubmed-meshheading:19321768-Extinction, Psychological, pubmed-meshheading:19321768-Extracellular Space, pubmed-meshheading:19321768-Glutamic Acid, pubmed-meshheading:19321768-Male, pubmed-meshheading:19321768-Nucleus Accumbens, pubmed-meshheading:19321768-Prefrontal Cortex, pubmed-meshheading:19321768-Rats, pubmed-meshheading:19321768-Rats, Sprague-Dawley, pubmed-meshheading:19321768-Self Administration, pubmed-meshheading:19321768-Synaptic Transmission
pubmed:year	2009
pubmed:articleTitle	A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens.
pubmed:affiliation	Department of Neurosciences and Neurobiology of Addiction Research Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural