Linked Life Data

19319856

Source:http://linkedlifedata.com/resource/pubmed/id/19319856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-3-25
pubmed:abstractText
A new class of reactive nucleosides, O(6)-(benzotriazol-1-yl) derivatives of inosine and 2'-deoxyinosine, have been developed via reaction of silyl-protected or unprotected inosine and 2'-deoxyinosine with 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP). Alternatively, the silyl-protected O(6)-(benzotriazol-1-yl) derivatives can be synthesized via reaction of protected inosine and 2'-deoxyinosine with triphenylphosphine/iodine/1-hydroxybenzotriazole. These new O(6)-(benzotriazol-1-yl) inosine derivatives are excellent reagents for the synthesis of other nucleoside analogues via S(N)Ar reaction with a range of nucleophiles.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1934-9289
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
Chapter 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
Unit 1.22
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
O6-(benzotriazol-1-yl)inosine derivatives for C6 modification of purine nucleosides.
pubmed:affiliation
The City College and The City University of New York, New York, USA.
pubmed:publicationType
Journal Article