Linked Life Data

19318432

Source:http://linkedlifedata.com/resource/pubmed/id/19318432

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-4-9
pubmed:abstractText
Genome-wide association studies have identified multiple common alleles associated with prostate cancer risk in populations of European ancestry. Testing these variants in other populations is needed to assess the generalizability of the associations and may guide fine-mapping efforts. We examined 13 of these risk variants in a multiethnic sample of 2,768 incident prostate cancer cases and 2,359 controls from the Multiethnic Cohort (African Americans, European Americans, Latinos, Japanese Americans, and Native Hawaiians). We estimated ethnic-specific and pooled odds ratios and tested for ethnic heterogeneity of effects using logistic regression. In ethnic-pooled analyses, 12 of the 13 variants were positively associated with risk, with statistically significant associations (P < 0.05) noted with six variants: JAZF1, rs10486567 [odds ratio (OR), 1.23; 95% confidence interval (95% CI, 1.12-1.35); Xp11.2, rs5945572 (OR, 1.31; 95% CI, 1.13-1.51); HNF1B, rs4430796 (OR, 1.15; 95% CI, 1.06-1.25); MSMB, rs10993994 (OR, 1.13; 95% CI, 1.04-1.23); 11q13.2, rs7931342 (OR, 1.13; 95% CI, 1.03-1.23); 3p12.1, rs2660753 (OR, 1.11; 95% CI, 1.01-1.21); SLC22A3, rs9364554 (OR, 1.10; 95% CI, 1.00-1.21); CTBP2, rs12769019 (OR, 1.11; 95% CI, 0.99-1.25); HNF1B, rs11649743 (OR, 1.10; 95% CI, 0.99-1.22); EHBP1, rs721048 (OR, 1.08; 95% CI, 0.94-1.25); KLK2/3, rs2735839 (OR, 1.06; 95% CI, 0.97-1.16); 17q24.3, rs1859962 (OR, 1.04; 95% CI, 0.96-1.13); and LMTK2, rs6465657 (OR, 0.99; 95% CI, 0.89-1.09). Significant ethnic heterogeneity of effects was noted for four variants (EHBP1, P(het) = 3.9 x 10(-3); 11q13, P(het) = 0.023; HNF1B (rs4430796), P(het) = 0.026; and KLK2/3, P(het) = 2.0 x 10(-3)). Although power was limited in some ethnic/racial groups due to variation in sample size and allele frequencies, these findings suggest that a large fraction of prostate cancer variants identified in populations of European ancestry are global markers of risk. For many of these regions, fine-mapping in non-European samples may help localize causal alleles and better determine their contribution to prostate cancer risk in the population.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-10695593, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-11575290, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-16515983, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-17401364, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-17603485, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-18264096, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-18264097, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-18264098, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-18418350, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-18708398, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-18758462, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-19165914, http://linkedlifedata.com/resource/pubmed/commentcorrection/19318432-8367293
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1285-9
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
pubmed:affiliation
Harlyne Norris Research Tower, Los Angeles, CA 90033, USA. kwaters@usc.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural