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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4290
|
| pubmed:dateCreated |
1977-6-11
|
| pubmed:abstractText |
Human osteosarcoma and mammary carcinoma cells were cultured separately in a medium supplemented with fetal calf serum, until they were confluent. The medium was then replaced by serum-free medium supplemented with heparin. Both cell cultures secreted collagenase, and this activity was inhibited by a cartilage-derived protein of low molecular weight. Since cartilage is rarely invaded by neoplasms, the presence of this inhibitor may play an important role in the regulation of tumor invasion.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0036-8075
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
196
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
653-4
|
| pubmed:dateRevised |
2007-3-19
|
| pubmed:meshHeading |
pubmed-meshheading:193181-Breast Neoplasms,
pubmed-meshheading:193181-Cartilage,
pubmed-meshheading:193181-Cells, Cultured,
pubmed-meshheading:193181-Heparin,
pubmed-meshheading:193181-Microbial Collagenase,
pubmed-meshheading:193181-Neoplasm Metastasis,
pubmed-meshheading:193181-Neoplasms, Experimental,
pubmed-meshheading:193181-Osteosarcoma
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Tumor cell collagenase and its inhibition by a cartilage-derived protease inhibitor.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|