| pubmed-article:19318122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19318122 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19318122 | lifeskim:mentions | umls-concept:C0038443 | lld:lifeskim |
| pubmed-article:19318122 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
| pubmed-article:19318122 | lifeskim:mentions | umls-concept:C0300926 | lld:lifeskim |
| pubmed-article:19318122 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19318122 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19318122 | lifeskim:mentions | umls-concept:C0574032 | lld:lifeskim |
| pubmed-article:19318122 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19318122 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19318122 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19318122 | pubmed:dateCreated | 2009-7-14 | lld:pubmed |
| pubmed-article:19318122 | pubmed:abstractText | The mobilization of cytotoxic lymphocytes, such Natural Killer (NK) cells and CD8(+) T cells, during stress and exercise is well documented in humans. However, humans have another cytotoxic lymphocyte subset that has not been studied in this context: the Gamma Delta (gammadelta) T lymphocyte. These cells play key roles in immune processes including the elimination of bacterial infection, wound repair and delayed-type hypersensitivity reactions. The current study investigated the effects of stress, exercise, and beta-agonist infusion on the mobilization of gammadelta T lymphocytes. Three separate studies compared lymphocytosis in response to an acute speech stress task (n=29), high (85%W(max)) and low (35%W(max)) intensity concentric exercise (n=11), and isoproterenol infusion at 20 and 40 ng/kg/min (n=12). Flow cytometric analysis was used to examine lymphocyte subsets. gammadelta T lymphocytes were mobilized in response to all three tasks in a dose-dependent manner; the extent of mobilization during the speech task correlated with concomitant cardiac activation, and was greater during higher intensity exercise and increased dose of beta-agonist infusion. The mobilization of gammadelta T lymphocytes was greater (in terms of % change from baseline) than that of CD8(+) T lymphocytes and less than NK cells. This study is the first to demonstrate that gammadelta T cells are stress-responsive lymphocytes which are mobilized during psychological stress, exercise, and beta-agonist infusion. The mobilization of these versatile cytotoxic cells may provide protection in the context of situations in which antigen exposure is more likely to occur. | lld:pubmed |
| pubmed-article:19318122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19318122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19318122 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19318122 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19318122 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19318122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19318122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19318122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19318122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19318122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19318122 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19318122 | pubmed:issn | 1090-2139 | lld:pubmed |
| pubmed-article:19318122 | pubmed:author | pubmed-author:MillsPaul JPJ | lld:pubmed |
| pubmed-article:19318122 | pubmed:author | pubmed-author:BurnsVictoria... | lld:pubmed |
| pubmed-article:19318122 | pubmed:author | pubmed-author:DraysonMark... | lld:pubmed |
| pubmed-article:19318122 | pubmed:author | pubmed-author:BoschJos AJA | lld:pubmed |
| pubmed-article:19318122 | pubmed:author | pubmed-author:WallaceGraham... | lld:pubmed |
| pubmed-article:19318122 | pubmed:author | pubmed-author:EdwardsKate... | lld:pubmed |
| pubmed-article:19318122 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:19318122 | pubmed:author | pubmed-author:RiddellNatali... | lld:pubmed |
| pubmed-article:19318122 | pubmed:author | pubmed-author:AnaneLeila... | lld:pubmed |
| pubmed-article:19318122 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19318122 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:19318122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19318122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19318122 | pubmed:pagination | 823-9 | lld:pubmed |
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| pubmed-article:19318122 | pubmed:meshHeading | pubmed-meshheading:19318122... | lld:pubmed |
| pubmed-article:19318122 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19318122 | pubmed:articleTitle | Mobilization of gammadelta T lymphocytes in response to psychological stress, exercise, and beta-agonist infusion. | lld:pubmed |
| pubmed-article:19318122 | pubmed:affiliation | School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, UK. | lld:pubmed |
| pubmed-article:19318122 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19318122 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
