Source:http://linkedlifedata.com/resource/pubmed/id/19318122
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2009-7-14
|
| pubmed:abstractText |
The mobilization of cytotoxic lymphocytes, such Natural Killer (NK) cells and CD8(+) T cells, during stress and exercise is well documented in humans. However, humans have another cytotoxic lymphocyte subset that has not been studied in this context: the Gamma Delta (gammadelta) T lymphocyte. These cells play key roles in immune processes including the elimination of bacterial infection, wound repair and delayed-type hypersensitivity reactions. The current study investigated the effects of stress, exercise, and beta-agonist infusion on the mobilization of gammadelta T lymphocytes. Three separate studies compared lymphocytosis in response to an acute speech stress task (n=29), high (85%W(max)) and low (35%W(max)) intensity concentric exercise (n=11), and isoproterenol infusion at 20 and 40 ng/kg/min (n=12). Flow cytometric analysis was used to examine lymphocyte subsets. gammadelta T lymphocytes were mobilized in response to all three tasks in a dose-dependent manner; the extent of mobilization during the speech task correlated with concomitant cardiac activation, and was greater during higher intensity exercise and increased dose of beta-agonist infusion. The mobilization of gammadelta T lymphocytes was greater (in terms of % change from baseline) than that of CD8(+) T lymphocytes and less than NK cells. This study is the first to demonstrate that gammadelta T cells are stress-responsive lymphocytes which are mobilized during psychological stress, exercise, and beta-agonist infusion. The mobilization of these versatile cytotoxic cells may provide protection in the context of situations in which antigen exposure is more likely to occur.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1090-2139
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
823-9
|
| pubmed:meshHeading |
pubmed-meshheading:19318122-Adrenergic beta-Agonists,
pubmed-meshheading:19318122-Carbon Dioxide,
pubmed-meshheading:19318122-Cell Count,
pubmed-meshheading:19318122-Exercise,
pubmed-meshheading:19318122-Female,
pubmed-meshheading:19318122-Flow Cytometry,
pubmed-meshheading:19318122-Heart Rate,
pubmed-meshheading:19318122-Hemodynamics,
pubmed-meshheading:19318122-Humans,
pubmed-meshheading:19318122-Infusions, Intravenous,
pubmed-meshheading:19318122-Isoproterenol,
pubmed-meshheading:19318122-Lymphocyte Subsets,
pubmed-meshheading:19318122-Male,
pubmed-meshheading:19318122-Oxygen,
pubmed-meshheading:19318122-Oxygen Consumption,
pubmed-meshheading:19318122-Social Environment,
pubmed-meshheading:19318122-Stress, Psychological,
pubmed-meshheading:19318122-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:19318122-Young Adult
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Mobilization of gammadelta T lymphocytes in response to psychological stress, exercise, and beta-agonist infusion.
|
| pubmed:affiliation |
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|