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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-11-27
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pubmed:abstractText |
Nocturnal symptoms are common and often disabling in asthmatic subjects. Furthermore, they often persist, in spite of appropriate dosages of inhaled beta 2-agonists and topical steroids. In such a clinical situation, theophylline preparations may have a therapeutic role. This double-blind, placebo-controlled, cross-over trial was designed to evaluate the effectiveness of a twice-daily Bioavail slow-release theophylline capsule in a group of out-patient asthmatics, with a history of nocturnal and/or early morning wheeze or chest tightness. Theophylline was initially prescribed and monitored in an 'open' phase to obtain the drug dosage required to achieve a serum level in the therapeutic range of 10-20 mg/l. In the ten patients who completed the study, serum theophylline levels were stable throughout. During active treatment there was an improvement in morning peak expiratory flow rate (PEFR), and a reduction in measurements of diurnal variation. In addition, the bronchodilator response to an inhaled beta 2-agonist was preserved. Bioavail theophylline has thus been shown to be an effective agent in the management of adults with nocturnal asthma.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0007-0947
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1931534-Adult,
pubmed-meshheading:1931534-Asthma,
pubmed-meshheading:1931534-Bronchodilator Agents,
pubmed-meshheading:1931534-Delayed-Action Preparations,
pubmed-meshheading:1931534-Double-Blind Method,
pubmed-meshheading:1931534-Drug Evaluation,
pubmed-meshheading:1931534-Female,
pubmed-meshheading:1931534-Humans,
pubmed-meshheading:1931534-Male,
pubmed-meshheading:1931534-Middle Aged,
pubmed-meshheading:1931534-Peak Expiratory Flow Rate,
pubmed-meshheading:1931534-Theophylline
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pubmed:year |
1991
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pubmed:articleTitle |
The effect of sustained-release theophylline in nocturnal asthma.
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pubmed:affiliation |
Department of Respiratory Physiology, East Birmingham Hospital.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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