Source:http://linkedlifedata.com/resource/pubmed/id/19309288
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-3-24
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| pubmed:abstractText |
We investigated the hypothesis that coinheritance of the common A(TA)(n)TAA promoter mutation at the UGT1A1 locus associated with Gilbert syndrome is a risk factor for gallstone formation in a homogeneous adult population, by conducting a case-control study that included 198 adult patients with cholelithiasis and 152 healthy controls both of Greek origin. Three genotypes were found: 7/7 (17.8% in controls and 23.3% in patients), 6/7 (33.5% in controls and 46.5% in patients), and normal homozygous 6/6 (48.7% in controls and 30.3% in patients). The Gilbert UGT1A1 genotypes 6/7 and 7/7 show significant association (odds ratio 2.225, 95% confidence interval 1.373-3.605, p=0.001, and odds ratio 2.101, 95% confidence interval 1.171-3.770, p=0.013, respectively) with cholelithiasis risk. This association supports the theory that genetic factors are responsible for a fraction of symptomatic gallstone disease; however, further studies are required in different ethnic groups to fully elucidate the involvement of Gilbert syndrome in gallstone disease.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1945-0257
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
143-6
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| pubmed:meshHeading |
pubmed-meshheading:19309288-Adolescent,
pubmed-meshheading:19309288-Adult,
pubmed-meshheading:19309288-Alleles,
pubmed-meshheading:19309288-Case-Control Studies,
pubmed-meshheading:19309288-Cholelithiasis,
pubmed-meshheading:19309288-DNA Repeat Expansion,
pubmed-meshheading:19309288-Dinucleotide Repeats,
pubmed-meshheading:19309288-Female,
pubmed-meshheading:19309288-Genetic Predisposition to Disease,
pubmed-meshheading:19309288-Genotype,
pubmed-meshheading:19309288-Gilbert Disease,
pubmed-meshheading:19309288-Glucuronosyltransferase,
pubmed-meshheading:19309288-Greece,
pubmed-meshheading:19309288-Humans,
pubmed-meshheading:19309288-Male,
pubmed-meshheading:19309288-Middle Aged,
pubmed-meshheading:19309288-Mutation,
pubmed-meshheading:19309288-Promoter Regions, Genetic,
pubmed-meshheading:19309288-Risk Factors,
pubmed-meshheading:19309288-Young Adult
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| pubmed:year |
2009
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| pubmed:articleTitle |
Gilbert syndrome as a predisposing factor for cholelithiasis risk in the Greek adult population.
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| pubmed:affiliation |
Laboratory of Cytogenetics and Medical Genetics, Medical School, University of Thessaly Larissa, Larissa, Greece.
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| pubmed:publicationType |
Journal Article
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