Linked Life Data

19308890

Source:http://linkedlifedata.com/resource/pubmed/id/19308890

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-3-24
pubmed:abstractText
Biological rhythms are a universal phenomenon in living organisms and serve to help organisms adapt within a circadian cycle to the 24-hour-oscillating environment. The rhythmic modulation of selective pathways thus enables organisms to optimize their ability to store and generate chemical energy, to minimize environmental stresses, and to reproduce by cycles of cell growth and division. Remarkably, the onset of both cardiovascular disorders and venous thromboembolism also undergoes circadian oscillations, which might be closely related to an internal biological clock. A highly repetitive rhythmic cycle seems to modulate platelet and endothelial functions, as well as the concentration and activity of several proteins of the coagulation and fibrinolytic systems. Although it is currently unknown how the global hemostatic efficiency might be affected by these circadian variations, understanding the nature, clinical significance, and pathophysiologic consequences of our hemostatic clock may be helpful for the prevention and treatment of a variety of conditions where either the severity of the illness or therapeutic efficacy exhibit circadian rhythmicity. In this review, clinical and laboratory data describing the effects of these cyclical rhythms on the hemostatic system are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1098-9064
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-33
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Circadian variation within hemostasis: an underrecognized link between biology and disease?
pubmed:affiliation
Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Verona, Italy.
pubmed:publicationType
Journal Article, Review